Exclusion of Identified LGMD1 Loci from Four Dominant Limb-Girdle Muscular Dystrophy Families

The limb-girdle muscular dystrophies are a clinically and genetically heterogeneous group of disorders. Recent linkage analyses and positional cloning studies have identified numerous loci responsible for the recessive and dominant forms, underscoring the inherent heterogeneity. In this report, we i...

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Bibliographic Details
Published in:Human heredity 1998-07, Vol.48 (4), p.179-184
Main Authors: Speer, Marcy C., Vance, Jeffery M., Lennon-Graham, Felicia, Stajich, Jeffrey M., Viles, Kristi D., Gilchrist, James M., Nigro, Vincenzo, McMichael, Robert, Chutkow, Jerry G., Bartoloni, Lucia, Horrigan, Steven K., Westbrook, Carol A., Pericak-Vance, Margaret A.
Format: Article
Language:English
Subjects:
Biological and medical sciences
Chromosomes, Human
Diseases of striated muscles. Neuromuscular diseases
Female
Genes, Dominant - genetics
Genes, Recessive
Genetic Linkage - genetics
Genetic Markers - genetics
Genotype
Haplotypes
Humans
Lod Score
Male
Medical sciences
Muscular Dystrophies - genetics
Neurology
Original Paper
Pedigree
Whites - genetics
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Summary:The limb-girdle muscular dystrophies are a clinically and genetically heterogeneous group of disorders. Recent linkage analyses and positional cloning studies have identified numerous loci responsible for the recessive and dominant forms, underscoring the inherent heterogeneity. In this report, we investigate four large autosomal dominant limb-girdle pedigrees and exclude these pedigrees from linkage to these loci. In addition, there is no evidence for linkage to any of the seven recessive LGMD loci.
ISSN:0001-5652
1423-0062
DOI:10.1159/000022799