Dopamine increases lung liquid clearance during mechanical ventilation

1  Pulmonary and Critical Care Medicine, Northwestern University, Chicago, Illinois 60611; and 2  Departamento de Enfermedades Respiratorias, Pontificia Universidad Católica de Chile, Santiago, Chile Short-term mechanical ventilation with high tidal volume (HVT) causes mild to moderate lung injury a...

Full description

Saved in:
Bibliographic Details
Published in:American journal of physiology. Lung cellular and molecular physiology 2002-07, Vol.283 (1), p.136-L143
Main Authors: Saldias, F. J, Comellas, A. P, Pesce, L, Lecuona, E, Sznajder, J. I
Format: Article
Language:English
Subjects:
Animals
Cardiotonic Agents - pharmacology
Cell Membrane Permeability - drug effects
Cell Membrane Permeability - physiology
Dopamine - pharmacology
Enzyme Activation - drug effects
Extravascular Lung Water - metabolism
Gene Expression Regulation, Enzymologic - drug effects
Male
Pulmonary Alveoli - cytology
Pulmonary Alveoli - drug effects
Pulmonary Alveoli - metabolism
Rats
Rats, Sprague-Dawley
Respiration, Artificial
Respiratory Mucosa - cytology
Respiratory Mucosa - drug effects
Respiratory Mucosa - metabolism
RNA, Messenger - analysis
Sodium-Potassium-Exchanging ATPase - genetics
Sodium-Potassium-Exchanging ATPase - metabolism
Specific Pathogen-Free Organisms
Tidal Volume
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:1  Pulmonary and Critical Care Medicine, Northwestern University, Chicago, Illinois 60611; and 2  Departamento de Enfermedades Respiratorias, Pontificia Universidad Católica de Chile, Santiago, Chile Short-term mechanical ventilation with high tidal volume (HVT) causes mild to moderate lung injury and impairs active Na + transport and lung liquid clearance in rats. Dopamine (DA) enhances active Na + transport in normal rat lungs by increasing Na + -K + -ATPase activity in the alveolar epithelium. We examined whether DA would increase alveolar fluid reabsorption in rats ventilated with HVT for 40 min compared with those ventilated with low tidal volume (LVT) and with nonventilated rats. Similar to previous reports, HVT ventilation decreased alveolar fluid reabsorption by ~50% ( P  
ISSN:1040-0605
1522-1504
DOI:10.1152/ajplung.00089.2000