Myocardial function defined by strain rate and strain during alterations in inotropic states and heart rate

Department of Cardiology, University Hospital Gasthuisberg, B-3000 Leuven, Belgium For porcine myocardium, ultrasonic regional deformation parameters, systolic strain ( sys ) and peak systolic strain rate (SR sys ), were compared with stroke volume (SV) and contractility [contractility index (CI)] m...

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Published in:American journal of physiology. Heart and circulatory physiology 2002-08, Vol.283 (2), p.H792-H799
Main Authors: Weidemann, Frank, Jamal, Fadi, Sutherland, George R, Claus, Piet, Kowalski, Miroslaw, Hatle, Liv, De Scheerder, Ivan, Bijnens, Bart, Rademakers, Frank E
Format: Article
Language:English
Subjects:
Adrenergic beta-Antagonists - pharmacology
Animals
Cardiac Pacing, Artificial
Cardiotonic Agents - pharmacology
Dobutamine - pharmacology
Echocardiography
Heart - drug effects
Heart - physiology
Heart Rate
Hemodynamics - drug effects
Myocardial Contraction
Propanolamines - pharmacology
Stress, Mechanical
Stroke Volume - drug effects
Swine
Systole
Ventricular Function, Left - drug effects
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Summary:Department of Cardiology, University Hospital Gasthuisberg, B-3000 Leuven, Belgium For porcine myocardium, ultrasonic regional deformation parameters, systolic strain ( sys ) and peak systolic strain rate (SR sys ), were compared with stroke volume (SV) and contractility [contractility index (CI)] measured as the ratio of end-systolic strain to end-systolic wall stress. Heart rate (HR) and contractility were varied by atrial pacing (AP = 120-180 beats/min, n  = 7), incremental dobutamine infusion (DI = 2.5-20 µg · kg 1 · min 1 , n  = 7), or continuous esmolol infusion (0.5 mg · kg 1 · min 1 ) + subsequent pacing (120-180 beats/min) (EI group, n  = 6). Baseline SR sys and sys averaged 5.0 ± 0.4 s 1 and 60 ± 4%. SR sys and CI increased linearly with DI (20 µg ·   kg 1 · min 1 ; SR sys  = 9.9 ± 0.7 s 1 , P  
ISSN:0363-6135
1522-1539
DOI:10.1152/ajpheart.00025.2002