Contributions of total and regional fat mass to risk for cardiovascular disease in older women

Divisions of 1  Geriatrics/Gerontology and 2  Biostatistics, Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri 63110; and 3  Division of Geriatric Medicine, Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262 The...

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Published in:American journal of physiology: endocrinology and metabolism 2002-05, Vol.282 (5), p.E1023-E1028
Main Authors: Van Pelt, R. E, Evans, E. M, Schechtman, K. B, Ehsani, A. A, Kohrt, W. M
Format: Article
Language:English
Subjects:
Abdomen
Absorptiometry, Photon
Adipose Tissue - anatomy & histology
Aged
Body Composition
Cardiovascular Diseases - diagnosis
Cardiovascular Diseases - epidemiology
Female
Glucose Tolerance Test
Humans
Hyperlipidemias - diagnosis
Hyperlipidemias - epidemiology
Insulin Resistance
Leg
Middle Aged
Multivariate Analysis
Obesity - diagnosis
Obesity - epidemiology
Postmenopause
Predictive Value of Tests
Risk Factors
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Summary:Divisions of 1  Geriatrics/Gerontology and 2  Biostatistics, Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri 63110; and 3  Division of Geriatric Medicine, Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262 The aim of this study was to determine whether trunk fat mass, measured by dual-energy X-ray absorptiometry (DEXA), is predictive of insulin resistance and dyslipidemia, independently of arm and leg fat mass, in postmenopausal women. Total and regional body composition was measured by DEXA in 166 healthy, postmenopausal women (66 ± 4 yr). Four primary markers of insulin resistance and dyslipidemia were assessed: 1 ) area under the curve for the insulin (INS AUC ) response to an oral glucose tolerance test (OGTT), 2 ) product of the OGTT glucose and insulin areas (INS AUC ×GLU AUC ), 3 ) serum triglycerides (TG), and 4 ) high-density lipoprotein (HDL)-cholesterol. Trunk fat mass was the strongest independent predictor of each of the primary dependent variables. In multivariate regression models, trunk fat mass was associated with unfavorable levels of INS AUC , INS AUC ×GLU AUC , TG, and HDL-C, whereas leg fat mass was favorably associated with each of these variables. Thus trunk fat is a strong independent predictor of insulin resistance and dyslipidemia in postmenopausal women, whereas leg fat appears to confer protective effects against metabolic dysfunction. trunk fat; leg fat; disease risk; postmenopausal women
ISSN:0193-1849
1522-1555
DOI:10.1152/ajpendo.00467.2001