5-HT 3 receptor antagonists for the prevention of perioperative shivering undergoing spinal anaesthesia: a systematic review and meta-analysis of randomised controlled trials

Perioperative shivering (POS) is a common complication in patients undergoing spinal anaesthesia. The present study investigated the efficacy of 5-HT receptor antagonists in preventing POS following spinal anaesthesia. Systematic review and meta-analysis. Pubmed, Embase, the Web of Science and Cochr...

Full description

Saved in:
Bibliographic Details
Published in:BMJ open 2020-10, Vol.10 (10), p.e038293
Main Authors: Shen, Qi-Hong, Li, Hui-Fang, Zhou, Xuyan, Lu, Yaping, Yuan, Xiao-Zong
Format: Article
Language:English
Subjects:
Anesthesia, Spinal - adverse effects
Humans
Pharmaceutical Preparations
Postoperative Nausea and Vomiting
Randomized Controlled Trials as Topic
Serotonin
Shivering
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Perioperative shivering (POS) is a common complication in patients undergoing spinal anaesthesia. The present study investigated the efficacy of 5-HT receptor antagonists in preventing POS following spinal anaesthesia. Systematic review and meta-analysis. Pubmed, Embase, the Web of Science and Cochrane Library were searched from database establishment on 31 July 2019. Randomised controlled trials that reported the effects of 5-HT receptor antagonists in the prevention of POS in patients after spinal anaesthesia. Two reviewers independently extracted data. The primary outcome of the present study was the incidence of POS. The risk of bias for the included studies was assessed according to the Cochrane Handbook. The quality of primary outcome was evaluated by Grading of Recommendations Assessment, Development and Evaluation. Trial sequential analysis for the primary outcome was performed to reduce the type 1 error caused by repeated meta-analysis and the required information size was calculated. A total of 13 randomised controlled trials consisting of 1139 patients were included. The overall incidence of POS was significantly lower in the 5-HT receptor antagonists group (risk ratio 0.31; 95% CI 0.26 to 0.38; p
ISSN:2044-6055
2044-6055
DOI:10.1136/bmjopen-2020-038293