Molecular Genetic Studies of Cognitive Ability

The paper presents a review of the results of molecular genetic studies of cognitive abilities. To date, a small number of genes responsible for normal cognitive functioning have been detected despite numerous studies based on the approach of candidate genes, genome-wide association studies, and lin...

Full description

Saved in:
Bibliographic Details
Published in:Russian journal of genetics 2019-07, Vol.55 (7), p.783-793
Main Authors: Malykh, S. B., Malykh, A. S., Karunas, A. S., Enikeeva, R. F., Davydova, Y. D., Khusnutdinova, E. K.
Format: Article
Language:English
Subjects:
Animal Genetics and Genomics
Biomedical and Life Sciences
Biomedicine
Human Genetics
Microbial Genetics and Genomics
Reviews and Theoretical Articles
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The paper presents a review of the results of molecular genetic studies of cognitive abilities. To date, a small number of genes responsible for normal cognitive functioning have been detected despite numerous studies based on the approach of candidate genes, genome-wide association studies, and linkage analyses. It should be considered that, even when the genetic variants were significantly associated with cognitive phenotypes, the sizes of the effect were usually very low (1–2%). However, large-scale genetic studies performed in the last few years significantly expanded the knowledge on the molecular basis of human cognitive abilities and made it possible to explain up to 20% of the 50% inheritance of intelligence.
ISSN:1022-7954
1608-3369
DOI:10.1134/S1022795419070111