Multicenter Study of Prevalence of Nontuberculous Mycobacteria in Patients with Cystic Fibrosis in France

We performed a multicenter prevalence study of nontuberculous mycobacteria (NTM) involving 1,582 patients (mean age, 18.9 years; male/female ratio, 1.06) with cystic fibrosis in France. The overall NTM prevalence (percentage of patients with at least one positive culture) was 6.6% (104/1,582 patient...

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Bibliographic Details
Published in:Journal of Clinical Microbiology 2009-12, Vol.47 (12), p.4124-4128
Main Authors: Roux, Anne-Laure, Catherinot, Emilie, Ripoll, Fabienne, Soismier, Nathalie, Macheras, Edouard, Ravilly, Sophie, Bellis, Gil, Vibet, Marie-Anne, Le Roux, Evelyne, Lemonnier, Lydie, Gutierrez, Cristina, Vincent, Véronique, Fauroux, Brigitte, Rottman, Martin, Guillemot, Didier, Gaillard, Jean-Louis
Format: Article
Language:English
Subjects:
Adolescent
Adult
Bacteriology
Biological and medical sciences
Child
Cystic Fibrosis
Cystic Fibrosis - epidemiology
Cystic Fibrosis - microbiology
Female
France
France - epidemiology
Fundamental and applied biological sciences. Psychology
Humans
Life Sciences
Lung Diseases
Lung Diseases - complications
Lung Diseases - epidemiology
Male
Microbiology
Miscellaneous
Mycobacteriology and Aerobic Actinomycetes
Mycobacterium abscessus
Mycobacterium avium
Mycobacterium avium Complex
Mycobacterium avium Complex - classification
Mycobacterium avium Complex - isolation & purification
Mycobacterium avium-intracellulare Infection
Mycobacterium avium-intracellulare Infection - epidemiology
Mycobacterium avium-intracellulare Infection - microbiology
Mycobacterium Infections, Nontuberculous
Mycobacterium Infections, Nontuberculous - epidemiology
Mycobacterium Infections, Nontuberculous - microbiology
Nontuberculous Mycobacteria
Nontuberculous Mycobacteria - classification
Nontuberculous Mycobacteria - isolation & purification
Prevalence
Santé publique et épidémiologie
Young Adult
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Summary:We performed a multicenter prevalence study of nontuberculous mycobacteria (NTM) involving 1,582 patients (mean age, 18.9 years; male/female ratio, 1.06) with cystic fibrosis in France. The overall NTM prevalence (percentage of patients with at least one positive culture) was 6.6% (104/1,582 patients), with prevalences ranging from 3.7% (in the east of France) to 9.6% (in the greater Paris area). Mycobacterium abscessus complex (MABSC; 50 patients) and Mycobacterium avium complex (MAC; 23 patients) species were the most common NTM, and the only ones associated with fulfillment of the American Thoracic Society bacteriological criteria for NTM lung disease. The "new" species, Mycobacterium bolletii and Mycobacterium massiliense, accounted for 40% of MABSC isolates. MABSC species were isolated at all ages, with a prevalence peak between 11 and 15 years of age (5.8%), while MAC species reached their highest prevalence value among patients over 25 years of age (2.2%).
ISSN:0095-1137
1098-660X
DOI:10.1128/JCM.01257-09