Gluconobacter as Well as Asaia Species, Newly Emerging Opportunistic Human Pathogens among Acetic Acid Bacteria

Acetic acid bacteria (AAB) are broadly used in industrial food processing. Among them, members of the genera Asaia, Acetobacter, and Granulibacter were recently reported to be human opportunistic pathogens. We isolated AAB from clinical samples from three patients and describe here the clinical and...

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Bibliographic Details
Published in:Journal of Clinical Microbiology 2010-11, Vol.48 (11), p.3935-3942
Main Authors: Alauzet, Corentine, Teyssier, Corinne, Jumas-Bilak, Estelle, Gouby, Anne, Chiron, Raphael, Rabaud, Christian, Counil, François, Lozniewski, Alain, Marchandin, Hélène
Format: Article
Language:English
Subjects:
Acetobacter
Acetobacteraceae - classification
Acetobacteraceae - isolation & purification
Anti-Bacterial Agents - pharmacology
Bacteriology
Biological and medical sciences
Cluster Analysis
DNA Fingerprinting
DNA, Bacterial - chemistry
DNA, Bacterial - genetics
DNA, Ribosomal - chemistry
DNA, Ribosomal - genetics
Electrophoresis, Gel, Pulsed-Field
Fundamental and applied biological sciences. Psychology
Genotype
Gluconobacter
Gram-Negative Bacterial Infections - diagnosis
Gram-Negative Bacterial Infections - microbiology
Gram-Negative Bacterial Infections - pathology
Humans
Life Sciences
Microbial Sensitivity Tests
Microbiology
Miscellaneous
Molecular Sequence Data
Opportunistic Infections - diagnosis
Opportunistic Infections - microbiology
Opportunistic Infections - pathology
Phylogeny
RNA, Ribosomal, 16S - genetics
Sequence Analysis, DNA
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Summary:Acetic acid bacteria (AAB) are broadly used in industrial food processing. Among them, members of the genera Asaia, Acetobacter, and Granulibacter were recently reported to be human opportunistic pathogens. We isolated AAB from clinical samples from three patients and describe here the clinical and bacteriological features of these cases. We report for the first time (i) the isolation of a Gluconobacter sp. from human clinical samples; (ii) the successive isolation of different AAB, i.e., an Asaia sp. and two unrelated Gluconobacter spp., from a cystic fibrosis patient; and (iii) persistent colonization of the respiratory tract by a Gluconobacter sp. in this patient. We reviewed the main clinical features associated with AAB isolation identified in the 10 documented reports currently available in the literature. Albeit rare, infections as well as colonization with AAB are increasingly reported in patients with underlying chronic diseases and/or indwelling devices. Clinicians as well as medical microbiologists should be aware of these unusual opportunistic pathogens, which are difficult to detect during standard medical microbiological investigations and which are multiresistant to antimicrobial agents. Molecular methods are required for identification of genera of AAB, but the results may remain inconclusive for identification to the species level.
ISSN:0095-1137
1098-660X
DOI:10.1128/JCM.00767-10