Porphyrin Induction: Equivalent Effects of 5αH and 5βH Steroids in Chick Embryo Liver Cells

The 5αH (A: B trans) and 5βH (A: B cis) steroids are equipotent in inducing δ-aminolevulinic acid synthetase and porphyrin accumulation in chick embryo liver cells maintained in serum-free culture medium. Thus there is no specific steric requirement for porphyrin-inducing activity in steroids.

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1977-08, Vol.197 (4304), p.659-660
Main Authors: Stephens, J. K., Fischer, P. W. F., Marks, G. S.
Format: Article
Language:English
Subjects:
Catechol estrogens
Catechols
Dosage
Embryos
Ethanol
Liver cells
Pharmacology
Porphyrins
Protein metabolism
Steroids
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Description
Summary:The 5αH (A: B trans) and 5βH (A: B cis) steroids are equipotent in inducing δ-aminolevulinic acid synthetase and porphyrin accumulation in chick embryo liver cells maintained in serum-free culture medium. Thus there is no specific steric requirement for porphyrin-inducing activity in steroids.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.877578