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Nicotine Dependence and Reward Differ between Adolescent and Adult Male Mice
The present study defined age differences in several aspects of nicotine dependence using male mice of two age groups [postnatal day (PND) 28 and PND 70]. Adolescent and adult mice displayed differences in acute sensitivity to nicotine, rewarding and withdrawal effects, development of tolerance to n...
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Published in: | The Journal of pharmacology and experimental therapeutics 2007-07, Vol.322 (1), p.399-407 |
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Main Authors: | , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | The present study defined age differences in several aspects of nicotine dependence using male mice of two age groups [postnatal
day (PND) 28 and PND 70]. Adolescent and adult mice displayed differences in acute sensitivity to nicotine, rewarding and
withdrawal effects, development of tolerance to nicotine, and nicotinic receptor function. In the condition place preference
model, adolescent mice displayed a higher sensitivity to nicotine than adults. In addition, in spontaneous and mecamylamine-precipitated
withdrawal models, adolescent mice displayed fewer withdrawal signs than adults. In response to acute nicotine, it was found
that adolescent mice displayed greater nicotine-induced antinociception compared with adult counterparts in the tail-flick
test. Furthermore, differences in tolerance to nicotine were also noted in that adolescents developed a significantly higher
degree of tolerance to nicotine in the hot-plate test compared with adults. Finally, using rubidium efflux assays, it was
found that adolescent nicotinic receptors in different brain areas displayed significantly increased functionality compared
with adult receptors. These data indicate that the underlying receptor mechanisms of nicotine dependence differ for adults
and adolescents, suggesting that the effectiveness of smoking cessation therapies will differ for various age groups. |
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ISSN: | 0022-3565 1521-0103 |
DOI: | 10.1124/jpet.107.121616 |