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Thromboelastographic evidence of inhibition of fibrinolysis after ε‐aminocaproic acid administration in a dog with suspected acute traumatic coagulopathy
Objective To describe the thromboelastographic changes in fibrinolysis with ε‐aminocaproic acid treatment in a dog with suspected acute traumatic coagulopathy. Case Summary A 9‐year‐old female spayed Airedale Terrier was presented with multiple injuries consistent with motor vehicle trauma. After su...
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| Published in: | Journal of veterinary emergency and critical care (San Antonio, Tex. : 2000) Tex. : 2000), 2016-09, Vol.26 (5), p.737-742 |
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| Language: | English |
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| container_end_page | 742 |
| container_issue | 5 |
| container_start_page | 737 |
| container_title | Journal of veterinary emergency and critical care (San Antonio, Tex. : 2000) |
| container_volume | 26 |
| creator | Yoo, Seung H. Venn, Emilee Sullivan, Lauren A. Olver, Christine S. |
| description | Objective
To describe the thromboelastographic changes in fibrinolysis with ε‐aminocaproic acid treatment in a dog with suspected acute traumatic coagulopathy.
Case Summary
A 9‐year‐old female spayed Airedale Terrier was presented with multiple injuries consistent with motor vehicle trauma. After surgical repair of a diaphragmatic hernia and minor laceration of the right cranial lung lobe, the dog continued to produce copious volumes of hemorrhagic fluid from the thoracic cavity despite multiple plasma transfusions, autotransfusions, and failure to locate a definitive source of bleeding during 2 separate surgeries. ε‐Aminocaproic acid treatment was initiated and was associated with rapid clinical improvement and diminished fibrinolysis based on a modified plasma‐based thromboelastogram.
New or Unique Information Provided
This report describes thromboelastographic evidence of inhibition of fibrinolysis after ε‐aminocaproic acid administration in a dog with suspected acute traumatic coagulopathy. Thromboelastrography may be useful in monitoring therapy with antifibrinolytic drugs. |
| doi_str_mv | 10.1111/vec.12467 |
| format | article |
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To describe the thromboelastographic changes in fibrinolysis with ε‐aminocaproic acid treatment in a dog with suspected acute traumatic coagulopathy.
Case Summary
A 9‐year‐old female spayed Airedale Terrier was presented with multiple injuries consistent with motor vehicle trauma. After surgical repair of a diaphragmatic hernia and minor laceration of the right cranial lung lobe, the dog continued to produce copious volumes of hemorrhagic fluid from the thoracic cavity despite multiple plasma transfusions, autotransfusions, and failure to locate a definitive source of bleeding during 2 separate surgeries. ε‐Aminocaproic acid treatment was initiated and was associated with rapid clinical improvement and diminished fibrinolysis based on a modified plasma‐based thromboelastogram.
New or Unique Information Provided
This report describes thromboelastographic evidence of inhibition of fibrinolysis after ε‐aminocaproic acid administration in a dog with suspected acute traumatic coagulopathy. Thromboelastrography may be useful in monitoring therapy with antifibrinolytic drugs.</description><identifier>ISSN: 1479-3261</identifier><identifier>EISSN: 1476-4431</identifier><identifier>DOI: 10.1111/vec.12467</identifier><identifier>PMID: 26990227</identifier><language>eng</language><publisher>United States</publisher><subject>acute coagulopathy of trauma‐shock ; Aminocaproic Acid - administration & dosage ; Aminocaproic Acid - therapeutic use ; Animals ; antifibrinolysis ; Antifibrinolytic Agents - administration & dosage ; Antifibrinolytic Agents - therapeutic use ; Blood Coagulation Disorders - drug therapy ; Blood Coagulation Disorders - veterinary ; canine ; Dog Diseases - drug therapy ; Dogs ; Female ; Thrombelastography - veterinary ; thromboelastography ; trauma‐induced coagulopathy</subject><ispartof>Journal of veterinary emergency and critical care (San Antonio, Tex. : 2000), 2016-09, Vol.26 (5), p.737-742</ispartof><rights>Veterinary Emergency and Critical Care Society 2016</rights><rights>Veterinary Emergency and Critical Care Society 2016.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4327-1ef0a2a4ae3af184bf2502e1643bb4b625b99d370726f0142ad910ed2582c6ce3</citedby><cites>FETCH-LOGICAL-c4327-1ef0a2a4ae3af184bf2502e1643bb4b625b99d370726f0142ad910ed2582c6ce3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fvec.12467$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fvec.12467$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,786,790,27957,27958,50923,51032</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26990227$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yoo, Seung H.</creatorcontrib><creatorcontrib>Venn, Emilee</creatorcontrib><creatorcontrib>Sullivan, Lauren A.</creatorcontrib><creatorcontrib>Olver, Christine S.</creatorcontrib><title>Thromboelastographic evidence of inhibition of fibrinolysis after ε‐aminocaproic acid administration in a dog with suspected acute traumatic coagulopathy</title><title>Journal of veterinary emergency and critical care (San Antonio, Tex. : 2000)</title><addtitle>J Vet Emerg Crit Care (San Antonio)</addtitle><description>Objective
To describe the thromboelastographic changes in fibrinolysis with ε‐aminocaproic acid treatment in a dog with suspected acute traumatic coagulopathy.
Case Summary
A 9‐year‐old female spayed Airedale Terrier was presented with multiple injuries consistent with motor vehicle trauma. After surgical repair of a diaphragmatic hernia and minor laceration of the right cranial lung lobe, the dog continued to produce copious volumes of hemorrhagic fluid from the thoracic cavity despite multiple plasma transfusions, autotransfusions, and failure to locate a definitive source of bleeding during 2 separate surgeries. ε‐Aminocaproic acid treatment was initiated and was associated with rapid clinical improvement and diminished fibrinolysis based on a modified plasma‐based thromboelastogram.
New or Unique Information Provided
This report describes thromboelastographic evidence of inhibition of fibrinolysis after ε‐aminocaproic acid administration in a dog with suspected acute traumatic coagulopathy. Thromboelastrography may be useful in monitoring therapy with antifibrinolytic drugs.</description><subject>acute coagulopathy of trauma‐shock</subject><subject>Aminocaproic Acid - administration & dosage</subject><subject>Aminocaproic Acid - therapeutic use</subject><subject>Animals</subject><subject>antifibrinolysis</subject><subject>Antifibrinolytic Agents - administration & dosage</subject><subject>Antifibrinolytic Agents - therapeutic use</subject><subject>Blood Coagulation Disorders - drug therapy</subject><subject>Blood Coagulation Disorders - veterinary</subject><subject>canine</subject><subject>Dog Diseases - drug therapy</subject><subject>Dogs</subject><subject>Female</subject><subject>Thrombelastography - veterinary</subject><subject>thromboelastography</subject><subject>trauma‐induced coagulopathy</subject><issn>1479-3261</issn><issn>1476-4431</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><recordid>eNp1kD1OxDAQhS0E4meh4ALILUXAdrwJKdGKPwmJBmijsTPeGCVxZCeg7TgCB-AaXINDcBK8u0DHNDPz9L1XPEIOOTvhcU6fUZ9wIbN8g-xymWeJlCnfXN1FkoqM75C9EJ4Y40UxFdtkR2RFwYTId8n7fe1dqxw2EAY399DXVlN8thV2Gqkz1Ha1VXawrlt-xipvO9csgg0UzICefn58vb5BG1UNvXfRDtpWFKoo2TB4WHltR4FWbk5f7FDTMIYe9YAR0-OANFJjG0FNtYP52LgehnqxT7YMNAEPfvaEPFxe3M-uk9u7q5vZ-W2iZSryhKNhIEACpmD4mVRGTJlAnslUKakyMVVFUaU5y0VmGJcCqoIzrMT0TOhMYzohx-tc7V0IHk3Ze9uCX5SclcuGy9hwuWo4skdrth9Vi9Uf-VtpBE7XwIttcPF_Uvl4MVtHfgNnlovV</recordid><startdate>201609</startdate><enddate>201609</enddate><creator>Yoo, Seung H.</creator><creator>Venn, Emilee</creator><creator>Sullivan, Lauren A.</creator><creator>Olver, Christine S.</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>201609</creationdate><title>Thromboelastographic evidence of inhibition of fibrinolysis after ε‐aminocaproic acid administration in a dog with suspected acute traumatic coagulopathy</title><author>Yoo, Seung H. ; Venn, Emilee ; Sullivan, Lauren A. ; Olver, Christine S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4327-1ef0a2a4ae3af184bf2502e1643bb4b625b99d370726f0142ad910ed2582c6ce3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>acute coagulopathy of trauma‐shock</topic><topic>Aminocaproic Acid - administration & dosage</topic><topic>Aminocaproic Acid - therapeutic use</topic><topic>Animals</topic><topic>antifibrinolysis</topic><topic>Antifibrinolytic Agents - administration & dosage</topic><topic>Antifibrinolytic Agents - therapeutic use</topic><topic>Blood Coagulation Disorders - drug therapy</topic><topic>Blood Coagulation Disorders - veterinary</topic><topic>canine</topic><topic>Dog Diseases - drug therapy</topic><topic>Dogs</topic><topic>Female</topic><topic>Thrombelastography - veterinary</topic><topic>thromboelastography</topic><topic>trauma‐induced coagulopathy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yoo, Seung H.</creatorcontrib><creatorcontrib>Venn, Emilee</creatorcontrib><creatorcontrib>Sullivan, Lauren A.</creatorcontrib><creatorcontrib>Olver, Christine S.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Journal of veterinary emergency and critical care (San Antonio, Tex. : 2000)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yoo, Seung H.</au><au>Venn, Emilee</au><au>Sullivan, Lauren A.</au><au>Olver, Christine S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Thromboelastographic evidence of inhibition of fibrinolysis after ε‐aminocaproic acid administration in a dog with suspected acute traumatic coagulopathy</atitle><jtitle>Journal of veterinary emergency and critical care (San Antonio, Tex. : 2000)</jtitle><addtitle>J Vet Emerg Crit Care (San Antonio)</addtitle><date>2016-09</date><risdate>2016</risdate><volume>26</volume><issue>5</issue><spage>737</spage><epage>742</epage><pages>737-742</pages><issn>1479-3261</issn><eissn>1476-4431</eissn><notes>The authors declare no conflicts of interest.</notes><notes>Presented in part as an oral case report presentation at the 19th International Veterinary Emergency and Critical Care Symposium, Sept 7‐11, 2013 San Diego, CA.</notes><abstract>Objective
To describe the thromboelastographic changes in fibrinolysis with ε‐aminocaproic acid treatment in a dog with suspected acute traumatic coagulopathy.
Case Summary
A 9‐year‐old female spayed Airedale Terrier was presented with multiple injuries consistent with motor vehicle trauma. After surgical repair of a diaphragmatic hernia and minor laceration of the right cranial lung lobe, the dog continued to produce copious volumes of hemorrhagic fluid from the thoracic cavity despite multiple plasma transfusions, autotransfusions, and failure to locate a definitive source of bleeding during 2 separate surgeries. ε‐Aminocaproic acid treatment was initiated and was associated with rapid clinical improvement and diminished fibrinolysis based on a modified plasma‐based thromboelastogram.
New or Unique Information Provided
This report describes thromboelastographic evidence of inhibition of fibrinolysis after ε‐aminocaproic acid administration in a dog with suspected acute traumatic coagulopathy. Thromboelastrography may be useful in monitoring therapy with antifibrinolytic drugs.</abstract><cop>United States</cop><pmid>26990227</pmid><doi>10.1111/vec.12467</doi><tpages>6</tpages></addata></record> |
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| identifier | ISSN: 1479-3261 |
| ispartof | Journal of veterinary emergency and critical care (San Antonio, Tex. : 2000), 2016-09, Vol.26 (5), p.737-742 |
| issn | 1479-3261 1476-4431 |
| language | eng |
| recordid | cdi_crossref_primary_10_1111_vec_12467 |
| source | Wiley-Blackwell Journals |
| subjects | acute coagulopathy of trauma‐shock Aminocaproic Acid - administration & dosage Aminocaproic Acid - therapeutic use Animals antifibrinolysis Antifibrinolytic Agents - administration & dosage Antifibrinolytic Agents - therapeutic use Blood Coagulation Disorders - drug therapy Blood Coagulation Disorders - veterinary canine Dog Diseases - drug therapy Dogs Female Thrombelastography - veterinary thromboelastography trauma‐induced coagulopathy |
| title | Thromboelastographic evidence of inhibition of fibrinolysis after ε‐aminocaproic acid administration in a dog with suspected acute traumatic coagulopathy |
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