Thromboelastographic evidence of inhibition of fibrinolysis after ε‐aminocaproic acid administration in a dog with suspected acute traumatic coagulopathy

Objective To describe the thromboelastographic changes in fibrinolysis with ε‐aminocaproic acid treatment in a dog with suspected acute traumatic coagulopathy. Case Summary A 9‐year‐old female spayed Airedale Terrier was presented with multiple injuries consistent with motor vehicle trauma. After su...

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Bibliographic Details
Published in:Journal of veterinary emergency and critical care (San Antonio, Tex. : 2000) Tex. : 2000), 2016-09, Vol.26 (5), p.737-742
Main Authors: Yoo, Seung H., Venn, Emilee, Sullivan, Lauren A., Olver, Christine S.
Format: Article
Language:English
Subjects:
acute coagulopathy of trauma‐shock
Aminocaproic Acid - administration & dosage
Aminocaproic Acid - therapeutic use
Animals
antifibrinolysis
Antifibrinolytic Agents - administration & dosage
Antifibrinolytic Agents - therapeutic use
Blood Coagulation Disorders - drug therapy
Blood Coagulation Disorders - veterinary
canine
Dog Diseases - drug therapy
Dogs
Female
Thrombelastography - veterinary
thromboelastography
trauma‐induced coagulopathy
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Summary:Objective To describe the thromboelastographic changes in fibrinolysis with ε‐aminocaproic acid treatment in a dog with suspected acute traumatic coagulopathy. Case Summary A 9‐year‐old female spayed Airedale Terrier was presented with multiple injuries consistent with motor vehicle trauma. After surgical repair of a diaphragmatic hernia and minor laceration of the right cranial lung lobe, the dog continued to produce copious volumes of hemorrhagic fluid from the thoracic cavity despite multiple plasma transfusions, autotransfusions, and failure to locate a definitive source of bleeding during 2 separate surgeries. ε‐Aminocaproic acid treatment was initiated and was associated with rapid clinical improvement and diminished fibrinolysis based on a modified plasma‐based thromboelastogram. New or Unique Information Provided This report describes thromboelastographic evidence of inhibition of fibrinolysis after ε‐aminocaproic acid administration in a dog with suspected acute traumatic coagulopathy. Thromboelastrography may be useful in monitoring therapy with antifibrinolytic drugs.
ISSN:1479-3261
1476-4431
DOI:10.1111/vec.12467