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Alterations in circulating concentrations of IL ‐17, IL ‐31 and total IgE in dogs with atopic dermatitis
Background The pathogenesis of canine atopic dermatitis ( AD ) is complex. Dysregulation of the cutaneous immune system is considered an important regulator of the allergic response. Exploration of association of interleukin‐17 ( IL ‐17), IL ‐31, IgE and leukogram attributes with canine AD could pro...
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| Published in: | Veterinary dermatology 2019-10, Vol.30 (5), p.383 |
|---|---|
| Main Authors: | , , , , , , |
| Format: | Article |
| Language: | English |
| Citations: | Items that this one cites |
| Online Access: | Get full text |
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| Summary: | Background
The pathogenesis of canine atopic dermatitis (
AD
) is complex. Dysregulation of the cutaneous immune system is considered an important regulator of the allergic response. Exploration of association of interleukin‐17 (
IL
‐17),
IL
‐31, IgE and leukogram attributes with canine
AD
could provide novel insights into its immunopathology.
Hypothesis/Objectives
To investigate possible associations of
IL
‐17,
IL
‐3, IgE and leukogram attributes of canine
AD
.
Animals
17 dogs diagnosed with
AD
and six healthy dogs.
Methods and materials
Circulating concentrations of
IL
‐17,
IL
‐31 and total IgE from sera samples were determined using commercial canine‐specific quantitative immunoassay kits. Complete blood cell counts were analysed by an automated haematology analyser. Statistical differences between the two groups were determined using an unpaired
t‐
test. The degree of relationship between the
IL
‐17,
IL
‐31, IgE, total leukocyte count (
TLC
) values and clinical signs scores (Canine Atopic Dermatitis Lesion Index and pruritus Visual Analog Scale p
VAS
) was determined by Pearson's
r
correlation statistic.
Results
Dogs with
AD
had significantly (
P
|
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| ISSN: | 0959-4493 1365-3164 |
| DOI: | 10.1111/vde.12762 |