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S taphylococcus aureus infections among children receiving a solid organ transplant: clinical features, epidemiology, and antimicrobial susceptibility
Abstract Background Staphylococcus aureus is among the most common causes of healthcare‐associated infection ( HAI ) in the United States. Patients who have received a solid organ transplant ( SOT ) represent a unique population for the acquisition of HAI s, given their preoperative organ failure, i...
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Published in: | Transplant infectious disease 2015-02, Vol.17 (1), p.39-47 |
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Main Authors: | , , , , |
Format: | Article |
Language: | English |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | Abstract
Background
Staphylococcus aureus
is among the most common causes of healthcare‐associated infection (
HAI
) in the United States. Patients who have received a solid organ transplant (
SOT
) represent a unique population for the acquisition of
HAI
s, given their preoperative organ failure, immunosuppression, and need for invasive procedures. However, limited literature is published on
S. aureus
infections among children with
SOT
. We describe the epidemiology, antimicrobial susceptibility, and clinical features of
S. aureus
infections among pediatric
SOT
recipients.
Design
An ongoing prospective
S. aureus
surveillance database from 2001 to 2012 was searched for infections in patients with a history of
SOT
at Texas Children's Hospital. Medical records and antibiotic susceptibility profiles were reviewed; specific attention was applied to the time since transplantation to infection.
Results
Out of the total of 696 transplants performed during the study period, 38 pediatric
SOT
recipients developed 41
S. aur
eus infections; the highest incidence of infection was among heart recipients. Overall, the most common infectious diagnoses were skin‐and‐soft‐tissue infections (66.1%), followed by bacteremia (15.3%). Among isolates in
SOT
patients, 47.5%, 16.9%, and 6.7% were resistant to methicillin, clindamycin, or mupirocin, respectively. Three infections (7.3%) occurred in the early post‐transplant period (6 months). In 10 cases (16.9%),
S. aureus
infection was associated with graft rejection during the same admission.
Conclusions
S. aureus
represents an important cause of morbidity in pediatric
SOT
recipients. While the majority of infections occurred late after transplant (>6 months), those acquired in the early post‐transplant period were more often invasive and caused by
MSSA
in our hospital. Physicians caring for
SOT
recipients should be aware of the risks posed by this pathogen and the potential concomitant morbidity including graft rejection. |
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ISSN: | 1398-2273 1399-3062 |
DOI: | 10.1111/tid.12331 |