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Feedback regulation of auxin signaling through the transcription of H2A.Z and deposition of H2A .Z to SMALL AUXIN UP RNAs in Arabidopsis
Summary Auxin is a critical phytohormone that is involved in the regulation of most plant growth and developmental responses. In particular, epigenetic mechanisms, like histone modifications and DNA methylation, were reported to affect auxin biosynthesis and transport. However, the involvement of ot...
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Published in: | The New phytologist 2022-12, Vol.236 (5), p.1721-1733 |
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Main Authors: | , , , , , , |
Format: | Article |
Language: | English |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | Summary
Auxin is a critical phytohormone that is involved in the regulation of most plant growth and developmental responses. In particular, epigenetic mechanisms, like histone modifications and DNA methylation, were reported to affect auxin biosynthesis and transport. However, the involvement of other epigenetic factors, such as histone variant H2A.Z, in the auxin‐related developmental regulation remains unclear.
We report that the histone variant
H2A.Z
knockdown mutant in
Arabidopsis
Col‐0 ecotype,
h2a.z‐kd
, has more lateral roots and weak gravitational responses related to auxin‐regulated growth performances. Further study revealed that auxin promotes the eviction of H2A.Z from the auxin‐responsive genes
SMALL AUXIN‐UP RNA
s (
SAUR
s) to activate their transcriptions.
We found that IAA promotes the transcription of
H2A.Z
genes through HOMEOBOX PROTEIN 22/25 (AtHB22/25) transcription factors which work as downstream targets of ARF7/19 in auxin signaling. Double mutant of
hb22 hb25
showed similar lateral root and gravitropism phenotypes to
h2a.z‐kd
.
Our results shed light on a reciprocal regulation hub through INOSITOL AUXOTROPHY 80‐mediated H2A.Z eviction and ARF7/19‐HB22/25‐mediated
H2A.Z
transcription to modulate the activation of
SAUR
s and plant growth in
Arabidopsis
. |
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ISSN: | 0028-646X 1469-8137 |
DOI: | 10.1111/nph.18440 |