Myeloid-derived suppressor cells from tumour-bearing mice induce the population expansion of CD19 hi FcγRIIb hi regulatory B cells via PD-L1

Myeloid-derived suppressor cells (MDSCs) increase in number and gain immunosuppressive functions in tumours and many other pathological conditions. MDSCs are characterized by their strong T-cell immunosuppressive capacity. The effects that MDSCs may have on B cells, especially within the tumour micr...

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Bibliographic Details
Published in:Immunology 2024-05, Vol.172 (1), p.127-143
Main Authors: Chen, Wenyan, Ning, Xiaomin, Liu, Yang, Shen, Tingting, Liu, Mengru, Yin, Hui, Ding, Yue, Zhou, Jingwen, Yin, Rui, Cai, Liangliang, Wu, Yuhan, Qian, Li
Format: Article
Language:English
Subjects:
Animals
B-Lymphocytes, Regulatory - metabolism
B7-H1 Antigen - metabolism
Cell Differentiation
Humans
Lung Neoplasms
Mice
Mice, Inbred C57BL
Myeloid-Derived Suppressor Cells - metabolism
Tumor Microenvironment
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Summary:Myeloid-derived suppressor cells (MDSCs) increase in number and gain immunosuppressive functions in tumours and many other pathological conditions. MDSCs are characterized by their strong T-cell immunosuppressive capacity. The effects that MDSCs may have on B cells, especially within the tumour microenvironment, are less well understood. Here, we report that either monocytic MDSCs or polymorphonuclear MDSCs can promote increases in interleukin (IL)-10-expressing CD19 FcγRIIb regulatory B cells in vitro and in vivo. Splenic transitional-1, -2, and -3 cells and marginal zone B cells, but not follicular B cells, differentiate into IL-10-expressing CD19 FcγRIIb regulatory B cells. The adoptive transfer of CD19 FcγRIIb regulatory B cells via tail vein injection can promote subcutaneous 3LL tumour growth in mice. The expression of programmed death-ligand 1 on MDSCs was found to be strongly associated with CD19 FcγRIIb regulatory B cell population expansion. Furthermore, the frequency of circulating CD19 FcγRII regulatory B cells was significantly increased in advanced-stage lung cancer patients. Our results unveil a critical role of MDSCs in regulatory B-cell differentiation and population expansion in lung cancer patients.
ISSN:0019-2805
1365-2567
DOI:10.1111/imm.13763