Pharmacological potential of the triterpene 3 β ,6 β ,16 β ‐trihidroxilup‐20 (29)‐ene isolated from Combretum leprosum : A literature review

Abstract Globally, plant‐derived medicines have been playing an increasing and relevant role in the treatment of several diseases, thus fostering the search for new bioactive substances. Among the various families of plants studied, those of the Combretum genus can be highlighted since they are wide...

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Published in:Fundamental & clinical pharmacology 2022-06, Vol.36 (3), p.486-493
Main Authors: Coutinho, Marnielle R., Oliveira, Larissa S., Evaristo, Francisco F. V., Marinho, Márcia M., Marinho, Emanuelle M., Teixeira, Edson H., Teixeira, Alexandre Magno R., Marinho, Emmanuel S., dos Santos, Hélcio S.
Format: Article
Language:English
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Summary:Abstract Globally, plant‐derived medicines have been playing an increasing and relevant role in the treatment of several diseases, thus fostering the search for new bioactive substances. Among the various families of plants studied, those of the Combretum genus can be highlighted since they are widely used in folk medicine for the treatment of hepatitis, malaria, respiratory infections, cancer, skin hemorrhage, and anxiety. Phytochemical studies carried out on species of the Combretum genus demonstrated the presence of several classes of bioactive chemical compounds, including the triterpene 3 β ,6 β ,16 β ‐trihydroxilup‐20(29)‐ene (CLF‐1). In this perspective, the objective of this review was to gather all pharmacological activities attributed to the CLF‐1 triterpene, highlighting its importance for the pharmaceutical industry. The research was performed in scientific databases such as PubMed, SciELO, LILACS, SciFinder and Science Direct. The literature indicates a great pharmacological potential of CLF‐1, evidencing its antioxidant, anti‐inflammatory, antiviral, antiparasitic, antinociceptive, healing, and antibacterial action, antinociceptive and antitumor effect. Therefore, based on the different research above, it is plausible to consider CLF‐1, obtained from different parts of the C. leprosum plant, as a molecule with biotechnological potential that may contribute to the development of new drugs and, consequently, in the treatment of various human pathologies.
ISSN:0767-3981
1472-8206
DOI:10.1111/fcp.12753