CD 4 + TCR γδ + FoxP3 + cells: An unidentified population of immunosuppressive cells towards disease progression leprosy patients

Abstract This study, for the first time, reveals the role of M. leprae ‐specific CD 4 + TCR γδ + FoxP3 + cells in the progression and pathogenesis of leprosy. Co‐culture with CD 4 + CD 25 − cells suggested the immunosuppressive nature of CD 4 + TCR γδ + cells in dose‐dependent manner. Isolation of C...

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Published in:Experimental dermatology 2017-10, Vol.26 (10), p.946-948
Main Authors: Tarique, Mohd, Naqvi, Raza A., Ali, Riyasat, Khanna, Neena, Rao, Donthamshetty Nageswara
Format: Article
Language:English
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Summary:Abstract This study, for the first time, reveals the role of M. leprae ‐specific CD 4 + TCR γδ + FoxP3 + cells in the progression and pathogenesis of leprosy. Co‐culture with CD 4 + CD 25 − cells suggested the immunosuppressive nature of CD 4 + TCR γδ + cells in dose‐dependent manner. Isolation of CD 4 + TCR γδ + cells from leprosy patients and then culture in presence of M. leprae cell wall antigens ( MLC wA) along with TGF β, IPP and IL ‐2 suggested that these cells are M. leprae specific. TGF ‐β‐mediated SMAD 3 signalling was turned out to be major factor towards the expression of FoxP3 in these cells. SMAD 3 silencing during induction of these cells barely showed the induction of FoxP3. High density of SMAD 3 binding at TGF β RII in CD 4 + TCR γδ + FoxP3 + furthermore suggested the TGF ‐β‐directed SMAD 3 signalling in these cells. Taken together the above data, we can conclude that CD 4 + TCR γδ + FoxP3 + cells possess the potential to track the severity of the disease in leprosy patients.
ISSN:0906-6705
1600-0625
DOI:10.1111/exd.13302