Changes in angiogenesis and hypoxia‐inducible factor‐1α protein expression in relapsed/refractory indolent non‐ H odgkin lymphomas

Summary Angiogenesis is involved in the pathogenesis and progression of non‐ H odgkin lymphomas ( NHL ), and hypoxia‐inducible factor‐1α ( HIF ‐1α, also termed HIF 1 A ) might contribute to this process. Currently, there is no direct evidence that the clinical progression of indolent NHL is associat...

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Published in:British journal of haematology 2013-12, Vol.163 (5), p.640-645
Main Authors: Minoia, Carla, Quero, Carmela, Asselti, Mariaconsilia, Galise, Ida, Marzano, Alessia L., Iacobazzi, Angela, Rana, Antonio, Merchionne, Francesca, Serratì, Simona, De Tullio, Giacoma, Quintana, Giovanni, Casiello, Michela, Maiorano, Eugenio, Simone, Giovanni, Zito, Francesco A., Iacopino, Pasquale, Guarini, Attilio
Format: Article
Language:English
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Summary:Summary Angiogenesis is involved in the pathogenesis and progression of non‐ H odgkin lymphomas ( NHL ), and hypoxia‐inducible factor‐1α ( HIF ‐1α, also termed HIF 1 A ) might contribute to this process. Currently, there is no direct evidence that the clinical progression of indolent NHL is associated with angiogenesis, and the expression of HIF ‐1α at recurrence is unknown. Matched lymph node biopsies at diagnosis and recurrence of relapsed/refractory indolent NHL patients were analysed by immunohistochemical and morphometric analysis. We observed an increased vascular network and HIF ‐1α protein expression in the second biopsy, providing direct evidence that angiogenesis is an essential process for disease progression.
ISSN:0007-1048
1365-2141
DOI:10.1111/bjh.12560