Resveratrol inhibits VEGF ‐induced angiogenesis in human endothelial cells associated with suppression of aerobic glycolysis via modulation of PKM 2 nuclear translocation

Summary Endothelial cells ( EC s) mainly depend on aerobic glycolysis to generate angiogenesis. Deregulation of glycolysis is often observed in human endothelial cells during angiogenesis. In the present study, we first report that resveratrol ( RST ), which has been intensively studied in glucose m...

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Published in:Clinical and experimental pharmacology & physiology 2018-12, Vol.45 (12), p.1265-1273
Main Authors: Wu, Hongyan, He, Liwei, Shi, JingJing, Hou, Xianbang, Zhang, Hongjiang, Zhang, Xiaoping, An, Qing, Fan, Fangtian
Format: Article
Language:English
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Summary:Summary Endothelial cells ( EC s) mainly depend on aerobic glycolysis to generate angiogenesis. Deregulation of glycolysis is often observed in human endothelial cells during angiogenesis. In the present study, we first report that resveratrol ( RST ), which has been intensively studied in glucose metabolism of various cancer cells, has a profound inhibitory effect on tube formation and migration via suppression of glycolysis in human umbilical vein endothelial cells ( HUVEC s) induced by vascular endothelial growth factor ( VEGF ). Moreover, we further reveal that RST reduced the mRNA and protein level of glucose transporter‐1( GLUT 1), hexokinase II ( HK 2), phosphofructokinase‐1( PFK 1) and pyruvate kinase M2 ( PKM 2) through modulation of ERK ‐mediated PKM 2 nuclear translocation. Our results provide a novel mechanism to account for the inhibition of RST on VEGF ‐mediated angiogenesis and suggest that targeting aerobic glycolysis or nuclear PKM 2 may be a new approach for pathological angiogenesis prevention or treatment.
ISSN:0305-1870
1440-1681
DOI:10.1111/1440-1681.13017