Quantum Entanglement Filtering: A PET Feasibility Study in Imaging Dual-Positron and Prompt Gamma Emission via Monte Carlo Simulation

In this article, we investigate quantum entanglement (QE) filtering to address the challenges in multi-isotope positron emission tomography (PET) or in PET studies utilizing radiotracers with dual-positron and prompt gamma emissions. Via GATE simulation, we demonstrate the efficacy of QE filtering u...

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Bibliographic Details
Published in:IEEE transactions on radiation and plasma medical sciences 2024, p.1-1
Main Authors: Romanchek, Gregory, Shoop, Greyson, Gholami, Kimia, Enlow, Emily, Abbaszadeh, Shiva
Format: Article
Language:English
Subjects:
GATE
Imaging
PET Imaging
Photonics
Positron emission tomography
Positrons
Prompt Gamma Imaging
Quantum entanglement
Radiotracer
Scattering
Simulation Study
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Summary:In this article, we investigate quantum entanglement (QE) filtering to address the challenges in multi-isotope positron emission tomography (PET) or in PET studies utilizing radiotracers with dual-positron and prompt gamma emissions. Via GATE simulation, we demonstrate the efficacy of QE filtering using a one-of-a-kind cadmium zinc telluride (CZT) PET system. establishing its viability as a multimodal scanner and ability to perform QE filtering. We show the high Compton scattering probability in this CZT-based scanner with 44.2% of gammas undergoing a single scatter prior to absorption. Additionally, the overall system sensitivity as a standard PET scanner (11.29%), QE-PET scanner (6.81%), and Compton Camera (11.29%) is quantified. Further, we find a 23% decrease in the double Compton scatter (DCSc) frequency needed for QE filtering for each mm decrease in crystal resolution and an increase in mean absolute error (MAE) of their δθs from 6.8∘ for 1 mm resolution to 9.5∘, 12.2∘, and 15.3∘ for 2, 4, and 8 mm resolution, respectively. These results reinforce the potential of CZT detectors to lead next generation PET systems taking full advantage of the QE information of positron annihilation photons.
ISSN:2469-7311
2469-7303
DOI:10.1109/TRPMS.2024.3388872