Renal effects of prostaglandins and clinical adverse effects of nonsteroidal anti-inflammatory agents

Non-steroidal anti-inflammatory agents ( NSAIA ) are increasingly used in clinical practice. They exert the majority of their therapeutic and adverse effects by inhibiting prostaglandin synthesis. A variety of clinically important side effects have been described following their administration. We r...

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Bibliographic Details
Published in:Medicine (Baltimore) 1984-05, Vol.63 (3), p.165-181
Main Authors: Garella, S, Matarese, R A
Format: Article
Language:English
Subjects:
Acute Kidney Injury - chemically induced
Adult
Aged
Anti-Inflammatory Agents - adverse effects
Anti-Inflammatory Agents - pharmacology
Blood Pressure - drug effects
Female
Glomerulonephritis - chemically induced
Hemodynamics - drug effects
Humans
Hyperkalemia - chemically induced
Hyponatremia - chemically induced
Kidney Diseases - chemically induced
Kidney Papillary Necrosis - chemically induced
Male
Middle Aged
Nephritis, Interstitial - chemically induced
Prostaglandin Antagonists - adverse effects
Prostaglandin Antagonists - pharmacology
Prostaglandins - physiology
Risk
Salicylates - adverse effects
Water-Electrolyte Balance - drug effects
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Summary:Non-steroidal anti-inflammatory agents ( NSAIA ) are increasingly used in clinical practice. They exert the majority of their therapeutic and adverse effects by inhibiting prostaglandin synthesis. A variety of clinically important side effects have been described following their administration. We review the renal complications, which include sodium retention, interference with the effectiveness of diuretics, impairment of water excretion, development of hyperkalemia, interference with the therapy of hypertension, and induction of at least four different forms of renal failure. The hemodynamic variety of renal failure and the side effects affecting fluid and electrolyte homeostasis are most likely to become manifest in the context of conditions leading to decreased renal perfusion. Guidelines for use of NSAIA , detection of patients at risk, and therapeutic approaches are provided.
ISSN:0025-7974
1536-5964
DOI:10.1097/00005792-198405000-00003