The effects of Meperidine and sufentanil on the shivering threshold in postoperative patients

Unlabelled BACKGROUND. Meperidine (pethidine) reportedly treats postoperative shivering better than equianalgesic doses of other mu-receptor agonists. The authors' first goal was to develop a method to accurately determine postoperative shivering thresholds, and then to determine the extent to...

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Bibliographic Details
Published in:Anesthesiology (Philadelphia) 1998-07, Vol.89 (1), p.43-48
Main Authors: ALFONSI, P, SESSLER, D. I, MANOIR, B. D, LEVRON, J.-C, LE MOING, J.-P, CHAUVIN, M
Format: Article
Language:English
Subjects:
Analgesics
Biological and medical sciences
Medical sciences
Neuropharmacology
Pharmacology. Drug treatments
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Summary:Unlabelled BACKGROUND. Meperidine (pethidine) reportedly treats postoperative shivering better than equianalgesic doses of other mu-receptor agonists. The authors' first goal was to develop a method to accurately determine postoperative shivering thresholds, and then to determine the extent to which meperidine and sufentanil inhibit postoperative shivering. Methods A computer-controlled infusion was started before operation in 30 patients, with target plasma concentrations of 0.15, 0.30, or 0.60 microg/ml meperidine or 0.1, 0.15, or 0.2 ng/ ml sufentanil targeted; patients were randomly assigned to each drug and concentration. The infusion was continued throughout surgery and recovery. Anesthesia was maintained with nitrous oxide and isoflurane. Core temperatures were approximately 34 degrees C by the end of surgery. The compensated core temperature at which visible shivering and a 20% decrease in steady-state oxygen consumption was recorded identified the shivering threshold. A blood sample for opioid concentration was obtained from each patient at this time. The ability of each opioid to reduce the shivering threshold was evaluated using linear regression. Results End-tidal isoflurane concentrations were
ISSN:0003-3022
1528-1175
DOI:10.1097/00000542-199807000-00009