Chronic Q fever: patient and treatment-related factors influencing long-term quality of life

Chronic Q fever is accompanied by high mortality and morbidity, and requires prolonged antibiotic treatment. Little is known on long-term quality of life (LQOL) in chronic Q fever patients treated with antibiotics. To identify patient and treatment-related factors associated with impaired LQOL in ch...

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Bibliographic Details
Published in:QJM : An International Journal of Medicine 2018-11, Vol.111 (11), p.791
Main Authors: van Roeden, S E, Reukers, D F M, van Jaarsveld, C H M, Kampschreur, L M, Hoepelman, I M, Wever, P C, Bleeker-Rovers, C P, Oosterheert, J J
Format: Article
Language:English
Subjects:
Aged
Anti-Bacterial Agents - adverse effects
Anti-Bacterial Agents - therapeutic use
Cross-Sectional Studies
Female
Humans
Logistic Models
Male
Middle Aged
Multivariate Analysis
Netherlands
Q Fever - diagnosis
Q Fever - drug therapy
Quality of Life
Surveys and Questionnaires
Time Factors
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Summary:Chronic Q fever is accompanied by high mortality and morbidity, and requires prolonged antibiotic treatment. Little is known on long-term quality of life (LQOL) in chronic Q fever patients treated with antibiotics. To identify patient and treatment-related factors associated with impaired LQOL in chronic Q fever patients treated with antibiotics, and to assess patients' perception on treatment. Cross-sectional study. LQOL was assessed with a validated questionnaire from the Nijmegen Clinical Screening Instrument. Patients' perception on treatment was measured with three newly developed questions. We included 64 patients: LQOL was impaired in 55% (n = 35) after a median follow-up of 5 years. Median treatment duration was 27 months. In multivariable analysis, treatment duration was significantly associated with impaired LQOL (OR 1.07; 95%CI 1.02-1.12, P 
ISSN:1460-2725
1460-2393
DOI:10.1093/qjmed/hcy171