P0496THE IMPORTANCE OF COMPLEMENT LEVELS AND CLINICAL CHARACTERISTICS OF PRIMARY MEMBRANOPROLIFERATIVE GLOMERULONEPHRITIS IN TURKEY

Abstract Background and Aims Membranoproliferative glomerulonephritis (MPGN) may be caused by disturbances in the complement system. Hypocomplementemia is a characteristic of MPGN. Among these patients frequency of hypocomplementemia and their relation with clinical and histopathological findings ar...

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Published in:Nephrology, dialysis, transplantation dialysis, transplantation, 2020-06, Vol.35 (Supplement_3)
Main Authors: Tatar, Erhan, Oygar, Deren, Seyahi, Nurhan, Eren, Necmi, Cantürk, Yağmur, Güngör, Özkan, Derici, Ülver, Sipahioğlu, Murat, Yıldız, Abdülmecit, Karadağ, Serhat, Sumnu, Abdullah, Odabas, Ali Riza, Turgut, Didem, Cavdar, Caner, SAHIN, Garip, Dursun, Belda, Guven Taymez, Dilek, Yılmaz Aydın, Fatma, Ulu, Memnune Sena, Basturk, Taner, Yadigar, Serap, Bozaci, Ilter, Behlül, Ahmet, Sipahi, Savaş, Bicik Bahçebaşı, Zerrin
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Language:English
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Summary:Abstract Background and Aims Membranoproliferative glomerulonephritis (MPGN) may be caused by disturbances in the complement system. Hypocomplementemia is a characteristic of MPGN. Among these patients frequency of hypocomplementemia and their relation with clinical and histopathological findings are still not clearly known. The aim of this study is to evaluate the hypocomplementemia frequency among the primary MPGN patients in Turkey and its relation with histopathological subtypes, findings and demographic characteristics. Method The data was obtained from national multicentered (47 centers) records of primary glomerular diseases in Glomerulonephritis Study Group of the Turkish Society of Nephrology database from May 2009 to June 2019. Primary MPGN cases were evaluated and divided into 2 groups with and without hypocomplementemia. Results In total, 193 cases were included in the study. The indications for renal biopsy were isolated nephrotic syndrome (55.4%), nephritic syndrome (21.2%), nephrotic syndrome with a nephritic component (6.2%) and asymptomatic urinary findings (17.2%). 34.2% of the cases were reported as immune complex type, another 34.2% of the cases were reported as C3 glomerulopathy. 31.6% of patients were not specified. 82 (42.4%) of the cases presented hypocomplementemia. Hypocomplementemic patients were younger (34±14 vs 41±15, p=0.002) and most frequently female (56% vs 41%, p=0.03). At same time, serum albumin and hemoglobin levels were lower and anemic patient rates were higher (p
ISSN:0931-0509
1460-2385
DOI:10.1093/ndt/gfaa142.P0496