P0484CLINICAL FEATURES AND OUTCOME OF LUPUS NEPHRITIS IN MOROCCO: A SINGLE CENTER STUDY OF 207 CASES

Abstract Background and Aims renal involvement is a common and potentially severe complication of systemic lupus erythematosus (SLE). Few data for Lupus nephritis (LN) exist on North Africans, especially those from Morocco. The aim of our study was to report the long-term renal outcome of a cohort o...

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Published in:Nephrology, dialysis, transplantation dialysis, transplantation, 2020-06, Vol.35 (Supplement_3)
Main Authors: Naouaoui, Salma, Chettati, Meriem, Fadili, Wafaa, Laouad, Inass
Format: Article
Language:English
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Summary:Abstract Background and Aims renal involvement is a common and potentially severe complication of systemic lupus erythematosus (SLE). Few data for Lupus nephritis (LN) exist on North Africans, especially those from Morocco. The aim of our study was to report the long-term renal outcome of a cohort of Moroccan patients with LN. Methods the records of 207 patients (191 females, 16 males) with LN (American College of Rheumatology criteria) admitted to the departments of nephrology and internal medicine of Marrakesh University Hospital were reviewed and included in a retrospective analysis. Results the mean age at the time of renal biopsy was 31,7 ±  15,9 years. Time between diagnosis of SLE and the onset of renal disease was 29 ± 10 months. Renal involvement was observed concomitantly with the onset of SLE in 39 patients (18,8%). At presentation, 65 patients (31,4%) had hypertension. Hematuria was seen in 158 patients (76,3%), nephrotic syndrome in 82 patients ( 39,6%) and renal failure in 76 patients (36,7%). The most frequent extarenal manifestations were skin and joint manifestations in 89,3% and 83,6% respectively. The most common histological finding was type IV LN in 96 patients, followed by type III LN in 51 patients. 191patients (92,3%) received corticosteroids as initial therapy followed by immunosuppressive therapy in 127 patients (61,3%). During the follow-up period, partial or total remission was obtained in 56,5% of cases while 61 patients (29,4%) progressed to end stage renal disease (ESRD) and 29 patients (14%) died. Logistic regression detected that hypertension, high serum creatinine at admission and proliferative histological classes were the main risk factors for poor renal outcome. Conclusion Our results showed that LN was particularly severe in our population compared with other published data with predominance of proliferative forms.
ISSN:0931-0509
1460-2385
DOI:10.1093/ndt/gfaa142.P0484