Snail and Slug mediate tamoxifen resistance in breast cancer cells through activation of EGFR-ERK independent of epithelial-mesenchymal transition

Breast cancer is the second most common type of cancer and the leading cause of cancer death in women worldwide. Adjuvant tamoxifen therapy significantly slows down estrogen receptor （ER）-positive breast cancer progression, prolongs diseasefree survival, and contributes to the decrease in breast can...

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Bibliographic Details
Published in:Journal of molecular cell biology 2014-08, Vol.6 (4), p.352-354
Main Authors: Jiang, Yan, Zhao, Xiaotong, Xiao, Qian, Liu, Qingbo, Ding, Keshuo, Yu, Fei, Zhang, Rui, Zhu, Tao, Ge, Gaoxiang
Format: Article
Language:English
Subjects:
Antineoplastic Agents, Hormonal - pharmacology
Breast Neoplasms - genetics
Breast Neoplasms - metabolism
Breast Neoplasms - pathology
Drug Resistance, Neoplasm
Epithelial-Mesenchymal Transition
Female
Humans
Mitogen-Activated Protein Kinase 1 - genetics
Mitogen-Activated Protein Kinase 1 - metabolism
Mitogen-Activated Protein Kinase 3 - genetics
Mitogen-Activated Protein Kinase 3 - metabolism
Receptor, Epidermal Growth Factor - genetics
Receptor, Epidermal Growth Factor - metabolism
Snail Family Transcription Factors
Tamoxifen - pharmacology
Transcription Factors - genetics
Transcription Factors - metabolism
Tumor Cells, Cultured
三苯氧胺
上皮
乳腺癌细胞
激活
耐药
蛞蝓
蜗牛
调解
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Summary:Breast cancer is the second most common type of cancer and the leading cause of cancer death in women worldwide. Adjuvant tamoxifen therapy significantly slows down estrogen receptor （ER）-positive breast cancer progression, prolongs diseasefree survival, and contributes to the decrease in breast cancer mortality （Musgrove and Sutherland, 2009）. However, majority of the death from breast cancer is due to metastasis that is resistant to therapy （Musgrove and Sutherland, 2009）.
ISSN:1674-2788
1759-4685
DOI:10.1093/jmcb/mju019