Multicomponent Analysis of Replacement Liquids of Electronic Cigarettes Using Chromatographic Techniques

The electronic cigarette (e-cig) is an invention of the past few years and its popularity is rapidly growing all over the world. A rapid multicomponent analytical protocol for the analysis of the replacement liquids (e-liquids) of e-cig was developed using gas (GC) and liquid chromatography (LC)–mas...

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Bibliographic Details
Published in:Journal of analytical toxicology 2015-05, Vol.39 (4), p.262-269
Main Authors: Kavvalakis, Matthaios P., Stivaktakis, Polychronis D., Tzatzarakis, Manolis N., Kouretas, Dimitrios, Liesivuori, Jyrki, Alegakis, Athanasios K., Vynias, Dionysios, Tsatsakis, Aristidis M.
Format: Article
Language:English
Subjects:
Chromatography, Liquid - methods
Electronic Nicotine Delivery Systems - standards
Ethylene Glycols - analysis
Gas Chromatography-Mass Spectrometry - methods
Glycerol - analysis
Limit of Detection
Monoterpenes - analysis
Nicotine - analysis
Nitrosamines - analysis
Polycyclic Aromatic Hydrocarbons - analysis
Propylene Glycol - analysis
Quality Control
Reproducibility of Results
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Summary:The electronic cigarette (e-cig) is an invention of the past few years and its popularity is rapidly growing all over the world. A rapid multicomponent analytical protocol for the analysis of the replacement liquids (e-liquids) of e-cig was developed using gas (GC) and liquid chromatography (LC)–mass spectrometry (MS). GC–MS-based methods were developed for the determination of the main humectants and polycyclic aromatic hydrocarbons (PAHs). For the determination and quantification of nicotine (NIC) and nitrosamines, appropriate LC–MS-based methods were developed. The approbated methods were applied for the analysis of 263 e-liquid samples obtained from the Greek market. The instruments response was linear; the limits of quantification ranged from 0.003 μg/mL for three PAHs to 1.187 μg/mL for glycerol. The precision was
ISSN:0146-4760
1945-2403
DOI:10.1093/jat/bkv002