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P–544 The results of embryo transfer cycles with low mosaic embryos: A case report
Abstract Study question What are the results of embryo transfer cycles with low mosaic embryos? Summary answer The clinical and ongoing pregnancy rates were 50%. The results of Amniocentesis were reported as normal karyotype for all the pregnant women. What is known already Many current studies, quo...
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| Published in: | Human reproduction (Oxford) 2021-08, Vol.36 (Supplement_1) |
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| Main Authors: | , , , , |
| Format: | Article |
| Language: | English |
| Online Access: | Get full text |
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| Summary: | Abstract
Study question
What are the results of embryo transfer cycles with low mosaic embryos?
Summary answer
The clinical and ongoing pregnancy rates were 50%. The results of Amniocentesis were reported as normal karyotype for all the pregnant women.
What is known already
Many current studies, quote the rates of mosaicism in blastocyst biopsies to be higher at 20–30%. Embryonic mosaicism was found to result from mitotic errors occurring after fertilization, occasionally in the first cleavage but more commonly in the second or third cleavage. The increased reporting of mosaicism in embryos has given rise to new challenges in PGS results interpretation and patient counseling. Previously, embryos were diagnosed as either euploid or aneuploid, and in most cases only euploid embryos were considered for transfer. Now, if mosaic embryos are considered to represent a third category of results.
Study design, size, duration
Case Report for The results of 10 embryo Transfer Cycles with Low Mosaic Embryos Participants/materials, setting, methods: We are presenting the results of ten embryo transfer cycles with low mosaic embryos at Bahceci BIH IVF Center, Sarajevo BIH, between January 2019 – October 2020. All the patients have been informed by a written informed consent form, and had genetic counseling before embryo transfer. Amniocentesis has been performed for all the pregnant women between 14–18 weeks of the pregnancy as prenatal testing.
Main results and the role of chance
Out of the total ten patients, 5 had pregnancy, and the 5 other were not pregnant. The average age of the whole group was; 34.0 ± 5.49 years. The average age of the pregnant women was ; 30.6 ± 5.54 years, and 37.40 ± 2.88 years who were not pregnant
Limitations, reasons for caution
There are limited number of papers in literature about transferring of the low mosaic embryos. The strength of our presentation is, amniocentesis have been performed as prenatal testing for all the pregnancies.
Wider implications of the findings: There were no correlation between the type of low mosaicism and pregnancy. Since all the pregnant women were 35 years of age or less, It was the only factor which is influencing the pregnancy.We hope that, the results of our cases will improve the management protocols for these cases.
Trial registration number
Not applicable |
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| ISSN: | 0268-1161 1460-2350 |
| DOI: | 10.1093/humrep/deab130.543 |