P5585Determinants of the use of direct oral anticoagulants in acute pulmonary thromboembolism in argentina

Abstract Background In the last decade, direct oral anticoagulants (DOACs) were incorporated as an alternative for anticoagulation in patients with venous thromboembolism. Although they have a better pharmacologic profile than vitamin K antagonists (VKAs), the use of these drugs is not massive. Purp...

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Published in:European heart journal 2019-10, Vol.40 (Supplement_1)
Main Authors: Bernal, M I, Scatularo, C E, Cigalini, I M, Jauregui, J C C, Ortego, J I, Cornejo, D, Aboy, J M, Burgos, L M, Gamarra, A L, Visconti, M, Garcia Zamora, S, Igolnikof, D B, Bonorino, J M, Zaidel, E J, Thierer, J
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Language:English
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Summary:Abstract Background In the last decade, direct oral anticoagulants (DOACs) were incorporated as an alternative for anticoagulation in patients with venous thromboembolism. Although they have a better pharmacologic profile than vitamin K antagonists (VKAs), the use of these drugs is not massive. Purpose Assess the rate of use of DOACs in acute pulmonary embolism (PE) patients (P) in Argentina and analyze the determinants of their use. Methods Based on a registry of 684 P admitted for acute PE in 75 academic centers between October 2016 and November 2017, we performed an analysis of DOACs prescription at discharge. A conventional statistical analysis was performed, to assess the differences between the P that received DOACs or other anticoagulants using univariate and multivariate models. Results 579 of 601 P who survived were discharged with anticoagulant treatment: 348 (60%) received VKA; 108 (19%) received DOACs (49% Rivaroxaban, 34% Apixaban, 17% Dabigatran) and 123 (21%) received low molecular weight heparins. Patients who received DOACs had lower severity of PE and less risk of bleeding. The main baseline characteristics are described in table 1. Also, those patients who received DOACs at discharge had fewer in-hospital complications (heart failure, infections or bleeding; all p
ISSN:0195-668X
1522-9645
DOI:10.1093/eurheartj/ehz746.0529