11β-Hydroxysteroid dehydrogenase type 2 activity is associated with left ventricular mass in essential hypertension

Aims Left ventricular mass (LVM) is under the control of aldosterone and angiotensin II in experimental hypertension, but the effect of aldosterone on LVM is controversial in essential hypertension (EH). Some EH patients show a mild impairment of 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2) ac...

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Published in:European heart journal 2005-03, Vol.26 (5), p.498-504
Main Authors: Glorioso, Nicola, Filigheddu, Fabiana, Parpaglia, Paolo Pinna, Soro, Aldo, Troffa, Chiara, Argiolas, Giuseppe, Mulatero, Paolo
Format: Article
Language:English
Subjects:
11β-Hydroxysteroid dehydrogenase
Blood pressure
Cardiac mass
Glucocorticoids
Mineralocorticoids
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Summary:Aims Left ventricular mass (LVM) is under the control of aldosterone and angiotensin II in experimental hypertension, but the effect of aldosterone on LVM is controversial in essential hypertension (EH). Some EH patients show a mild impairment of 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2) activity without clinical features of the syndrome of apparent mineralocorticoid excess, where the incomplete cortisol-to-cortisone conversion leads to glucocorticoid-mediated mineralocorticoid effects. The mineralocorticoid receptor and 11β-HSD2 are co-expressed in human heart. We investigated whether LVM may be regulated by glucocorticoids in EH patients. Methods and results The ratio between 24 h urinary tetrahydro derivatives of cortisol and cortisone (THFs/THE), plasma renin activity, 24 h urinary aldosterone, blood pressure, and LVM indexed for height2.7 (LVMh2.7) were analysed in 493 never-treated hypertensives and 98 normotensives. THFs/THE was associated with LVMh2.7 in hypertensives and normotensives (r=0.32, P
ISSN:0195-668X
1522-9645
DOI:10.1093/eurheartj/ehi070