The role of peak NT-proBNP/peak cardiac troponin T ratio obtained within 3 days of admission to discriminate Takotsubo from acute coronary syndrome

Abstract Background Takotsubo syndrome (TS) is not usually diagnosed until a patient with suspected acute coronary syndrome (ACS) is found to have no hemodynamically significant lesions on coronary angiography (CA). Purpose We explored whether a cardiac biomarker profile can contribute to early diag...

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Published in:European heart journal 2022-10, Vol.43 (Supplement_2)
Main Authors: Rallidis, L, Kosmas, N, Iordanidis, D, Kiouri, E, Zapantiotis, D, Samiotis, E, Varounis, C, Filippatos, G
Format: Article
Language:English
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Summary:Abstract Background Takotsubo syndrome (TS) is not usually diagnosed until a patient with suspected acute coronary syndrome (ACS) is found to have no hemodynamically significant lesions on coronary angiography (CA). Purpose We explored whether a cardiac biomarker profile can contribute to early diagnosis of TS, which could be useful when CA is either not available or does not provide a definitive diagnosis. Methods Ratios of N-terminal-pro brain natriuretic peptide (NT-proBNP) and cardiac troponin T (cTnT) [admission and peak levels of the two consecutive days following admission, expressed in pg/mL] were compared in 41 patients with TS and 50 ACS patients. Results Both admission NT-proBNP/cTnT ratio and peak NT-proBNP/peak cTnT ratio were higher in patients with TS compared to those with ACS (38.8±57.1 vs 15.2±33.1, p=0.038 and 29.1±26.2 vs 2.2±3.9, p
ISSN:0195-668X
1522-9645
DOI:10.1093/eurheartj/ehac544.1464