Sex related differences in vascular interventions and outcome of patients with critical limb threatening ischemia in a real-world cohort

Abstract Background The prevalence of critical limb threatening ischemia (CLTI) is increasing worldwide and the focus is the reduction of outcome events like death or amputation of the lower limb (LL). Sex related differences in medical supply and outcome are a current matter of debate. Purpose In t...

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Published in:European heart journal 2021-10, Vol.42 (Supplement_1)
Main Authors: Makowski, L, Feld, J, Koeppe, J, Engelbertz, C, Illner, J, Kuehnemund, L, Fischer, A, Lange, S A, Droege, P, Guenster, C, Gerss, J, Reinecke, H, Freisinger, E
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Language:English
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Summary:Abstract Background The prevalence of critical limb threatening ischemia (CLTI) is increasing worldwide and the focus is the reduction of outcome events like death or amputation of the lower limb (LL). Sex related differences in medical supply and outcome are a current matter of debate. Purpose In the present study, we included patients with CLTI in an unselected “real-world” cohort and studied sex related differences in their risk profile and vascular interventions, as well as their impact on long-term outcome. Methods We analyzed 119,953 unselected patients of the public health insurance in Germany (AOK), which were hospitalized between 2010 and 2017 for a main diagnosis of CLTI (Rutherford stage (RF) 4–6). In our data files, a baseline period of 2 years previous index hospitalization and a follow-up period until 2018 was included. Results In our cohort, more than half were male CLTI patients (57% male vs. 43% female), while female CLTI patients were at higher age (median: 73.8 years male vs. 81.4 years female). Male patients had higher ratios of diabetes, dyslipidemia, smoking, cerebrovascular disease and chronic coronary syndrome, whereas female CLTI patients show a higher prevalence of hypertension, atrial fibrillation, chronic heart failure and chronic kidney disease (all p
ISSN:0195-668X
1522-9645
DOI:10.1093/eurheartj/ehab724.2038