Association of COVID-19 with impaired endothelial glycocalyx, coronary flow and longitudinal strain four months after infection

Abstract Funding Acknowledgements Type of funding sources: None. Aims SARS-CoV-2 infection may lead to endothelial and vascular dysfunction. We investigated alterations of arterial stiffness, endothelial coronary and myocardial function markers four months after COVID-19 infection. Methods In a case...

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Published in:European heart journal cardiovascular imaging 2022-02, Vol.23 (Supplement_1)
Main Authors: Ikonomidis, I, Katogiannis, K, Mitrakou, A, Kountouri, A, Thymis, J, Korakas, E, Varlamos, C, Andreadou, I, Tsoumani, M, Bamias, A, Kazakou, P, Grigoropoulou, S, Kavatha, D, Dimopoulos, MA, Lambadiari, V
Format: Article
Language:English
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Summary:Abstract Funding Acknowledgements Type of funding sources: None. Aims SARS-CoV-2 infection may lead to endothelial and vascular dysfunction. We investigated alterations of arterial stiffness, endothelial coronary and myocardial function markers four months after COVID-19 infection. Methods In a case-control prospective study, we included 100 patients four months after COVID-19 infection, 50 age- and sex-matched healthy individuals. We measured a) perfused boundary region (PBR) of the sublingual arterial microvessels (increased PBR indicates reduced endothelial glycocalyx thickness), b) flow-mediated dilation (FMD), c) coronary Flow Reserve (CFR) by Doppler echocardiography d) pulse wave velocity (PWV) e) global left (LV) and right (RV) ventricular longitudinal strain (GLS), f) malondialdehyde (MDA), an oxidative stress marker, von-Willenbrand factor and thrombomodulin as endothelial biomarkers. Results COVID-19 patients had lower CFR and FMD values than controls (2.39 ± 0.39 vs 3.31 ± 0.59, p = 0.0122, 5.12 ± 2.95% vs 8.12 ± 2.23%, p = 0.006 respectively). Compared to controls, COVID-19 had greater PBR5-25 (2.11 ± 0.14μm vs 1.87 ± 0.16μm, p = 0.002), higher PWV (PWVc-f 12.32 ± 2.44 vs 10.11 ± 1.85 m/sec, p = 0.033) and impaired LV and RV GLS (-19.11 ± 2.14% vs -20.41 ± 1.61%, p = 0.001 and -16.45 ± 3.33% vs -20.11 ± 2.48%, p 
ISSN:2047-2404
2047-2412
DOI:10.1093/ehjci/jeab289.313