Effects of anti-inflammatory treatment and surgical intervention on endothelial glycocalyx, peripheral and coronary microcirculation and myocardial deformation in inflammatory bowel disease patients

Abstract Funding Acknowledgements Type of funding sources: Foundation. Main funding source(s): EOMIFNE (Hellenic Society of IBD study) Introduction IBD alter gastrointestinal physiology and mucosal immunity through a complex inflammatory process which leads to significant arterial endothelial dysfun...

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Published in:European heart journal cardiovascular imaging 2021-02, Vol.22 (Supplement_1)
Main Authors: Triantafyllou, C, Ikonomidis, I, Nikolaou, M, Bamias, G, Thymis, J, Kostelli, G, Kalogeris, A, Papaconstantinou, I
Format: Article
Language:English
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Summary:Abstract Funding Acknowledgements Type of funding sources: Foundation. Main funding source(s): EOMIFNE (Hellenic Society of IBD study) Introduction IBD alter gastrointestinal physiology and mucosal immunity through a complex inflammatory process which leads to significant arterial endothelial dysfunction and modification of cardiac structure and function. This study is performed to test the hypothesis that treatment with TNF-a inhibitor or surgical intervention improves cardiovascular function through anti-inflammatory mechanisms. Methods 57 IBD patients (45 CD and 12 UC, 40 ± 8 years, 57% male) were examined at baseline and 4 months after pharmaceutical (antiTNF-a) or surgical intervention. Subjects with a history of established cardiovascular risk factors were excluded. We measured a) carotid-femoral pulse wave velocity (PWV - Complior SP ALAM) and augmentation index (AI), b) flow mediated dilatation (FMD) of the brachial artery), c) perfused boundary region (PBR) of the sublingual arterial microvessels, d) LV longitudinal strain (GLS) and (PWV/GLS) as a marker of ventricular-arterial coupling, e) peak LV twisting, peak twisting velocity (pTwVel) and peak untwisting velocity (pUtwVel) using speckle tracking echocardiography, f) mitral annulus velocities by tissue doppler imaging (S’ and E’) and mitral inflow velocity (E), g) coronary flow reserve (CFR) by Doppler echocardiography, h) C-reactive protein (CRP), white blood cells (WBC). IBD severity was quantified using Mayo score and Harvey-Bradshaw Index (HBI) for UC and CD respectively. Results At baseline, the disease severity score and the WBC values were significantly correlated with peripheral PWV (r = 0.3, p 
ISSN:2047-2404
2047-2412
DOI:10.1093/ehjci/jeaa356.423