P165 Infliximab trough levels during maintenance are predictive for infliximab efficacy in paediatric patients with inflammatory bowel disease
Abstract Background The role of therapeutic drug monitoring during maintenance treatment in paediatric inflammatory bowel disease (IBD) is poorly studied. The aim was to determine whether infliximab (IFX) trough levels (TL) correlate with long-term remission in children receiving maintenance IFX. Me...
Saved in:
| Published in: | Journal of Crohn's and colitis 2018-01, Vol.12 (supplement_1), p.S180-S181 |
|---|---|
| Main Authors: | , , , , , |
| Format: | Article |
| Language: | eng |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | Abstract
Background
The role of therapeutic drug monitoring during maintenance treatment in paediatric inflammatory bowel disease (IBD) is poorly studied. The aim was to determine whether infliximab (IFX) trough levels (TL) correlate with long-term remission in children receiving maintenance IFX.
Methods
In this cross-sectional study all children with Crohn’s disease (CD) or ulcerative colitis (UC) receiving maintenance IFX at our referral centre were included. All children received pro-active drug monitoring with the therapeutic window defined between 3–7 µg/ml (conform adult studies). IFX TL were analysed using the Ridascreen IFX Monitoring ELISA. Demographics, disease activity indices, biochemical values and endoscopic reports were recorded retrospectively. Clinical remission was defined as PUCAI/PCDAI |
|---|---|
| ISSN: | 1873-9946 1876-4479 |