Natural T, γδ, and NK Cells in Mycobacterial, Salmonella, and Human Immunodeficiency Virus Infections

NK cells, γδ T cell antigen receptor chain-positive cells, and CD3+CD16/56+ (natural T [NT]) cells are involved in innate immunity and immunoregulation; however, their role in clinical infection is not well defined. Cytofluorometric analysis was used to examine peripheral blood from bacteremic, nonb...

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Bibliographic Details
Published in:	The Journal of infectious diseases 2000-08, Vol.182 (2), p.474-481
Main Authors:	Jason, Janine, Buchanan, Ian, Archibald, Lennox K., Nwanyanwu, Okey C., Bell, Michael, Green, Timothy A., Eick, Angelia, Han, Alison, Razsi, Dustin, Kazembe, Peter N., Dobbie, Hamish, Midathada, Madhu, Jarvis, William R.
Format:	Article
Language:	eng
Subjects:	AIDS Biological and medical sciences Blood Cytokines HIV Human viral diseases Infections Infectious diseases Lymphocytes Major Articles Medical sciences Natural killer cells Natural killer T cells Salmonella T lymphocytes Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids
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Summary:	NK cells, γδ T cell antigen receptor chain-positive cells, and CD3+CD16/56+ (natural T [NT]) cells are involved in innate immunity and immunoregulation; however, their role in clinical infection is not well defined. Cytofluorometric analysis was used to examine peripheral blood from bacteremic, nonbacteremic, and healthy human immunodeficiency virus (HIV)—positive and —negative persons in Malawi, Africa. Mycobacteremia was associated with a higher proportion of CD3+CD8− γδ cells (median, 16.6% vs. 0.7% for all other cells; P < .001), and Salmonella bacteremia was associated with a higher proportion of NT cells (4.3% vs. 2.2%; P = .002). HIV plasma RNA levels were weakly positively correlated with NT cells (rs = .39; P = .002), NK cells (rs = .38; P = .003), and γδ cells (rs = .43; P< .001). Compared with patients who survived, patients who died had a higher percentage of NT cells (3.7% vs. 1.9%; P = .017) and a higher percentage of NT cells that spontaneously produced interferon-γ (2.4% vs. 1.2%; P = .035). The data support the clinical relevance of γδ and NT cells in mycobacterial, Salmonella, and HIV infections and of NT cells in mortality.
ISSN:	0022-1899 1537-6613