Effect of Zidovudine Resistance Mutations on Virologic Response to Treatment with Zidovudine-Lamivudine-Ritonavir: Genotypic Analysis of Human Immunodeficiency Virus Type 1 Isolates from AIDS Clinical Trials Group Protocol 315

The effect of baseline drug resistance mutations on response to zidovudine, lamivudine, and ritonavir was evaluated in zidovudine-experienced persons infected with human immunodeficiency virus type 1 (HIV-1). Presence of the K70R mutation was associated with significantly higher plasma HIV-1 RNA lev...

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Bibliographic Details
Published in:The Journal of infectious diseases 2000-02, Vol.181 (2), p.491-497
Main Authors: Kuritzkes, Daniel R., Sevin, Anne, Young, Benjamin, Bakhtiari, Minoo, Wu, Hulin, St. Clair, Marty, Connick, Elizabeth, Landay, Alan, Spritzler, John, Kessler, Harold, Lederman, Michael M.
Format: Article
Language:English
Subjects:
AIDS
Antiretrovirals
Antivirals
Biological and medical sciences
Codons
Genetic mutation
HIV
HIV 1
Human viral diseases
Infectious diseases
Major Articles
Medical sciences
RNA
Viral diseases
Viral diseases of the lymphoid tissue and the blood. Aids
Virology
Viruses
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Summary:The effect of baseline drug resistance mutations on response to zidovudine, lamivudine, and ritonavir was evaluated in zidovudine-experienced persons infected with human immunodeficiency virus type 1 (HIV-1). Presence of the K70R mutation was associated with significantly higher plasma HIV-1 RNA levels at baseline. However, presence of resistance mutations did not affect the increase in plasma HIV-1 RNA during a 5-week drug washout, nor was there any effect on first-phase virus decay rates after initiation of therapy or on the probability of having plasma HIV-1 RNA levels
ISSN:0022-1899
1537-6613
DOI:10.1086/315244