CONTROL OF DNA CONFORMATION USING 3′-S-PHOSPHOROTHIOLATE-MODIFIED LINKAGES

An in-depth study into the incorporation of multiple 3′-S-phosphorothiolate modifications into oligodeoxynucleotides (ODNs) and their subsequent effect on ODN/DNA and ODN/RNA duplex stability. 3′-S-Phosphorothiolate linkages increase the stability of ODN/RNA duplexes and decrease the stability of OD...

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Bibliographic Details
Published in:Nucleosides, nucleotides & nucleic acids nucleotides & nucleic acids, 2005-01, Vol.24 (5-7), p.491-495
Main Authors: Buckingham, Joanne, Sabbagh, Ghalia, Brazier, John, Fisher, Julie, Cosstick, Rick
Format: Article
Language:English
Subjects:
DNA - chemistry
Models, Chemical
Molecular Conformation
Nucleic Acid Conformation
Nucleic Acid Heteroduplexes - chemistry
Oligonucleotides - chemistry
Phosphorus - chemistry
RNA - chemistry
Temperature
Thermodynamics
Thionucleotides - chemistry
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Summary:An in-depth study into the incorporation of multiple 3′-S-phosphorothiolate modifications into oligodeoxynucleotides (ODNs) and their subsequent effect on ODN/DNA and ODN/RNA duplex stability. 3′-S-Phosphorothiolate linkages increase the stability of ODN/RNA duplexes and decrease the stability of ODN/DNA duplexes.
ISSN:1525-7770
1532-2335
DOI:10.1081/NCN-200061776