Macrocyclic Antibiotics as Chiral Selectors in the Design of Enantioselective, Potentiometric Membrane Electrodes

Two enantioselective, potentiometric membrane electrodes, based on macrocyclic glycopeptide antibiotics-vancomycin and teicoplanin-were designed. Acetyl-L-carnitine was selected as model analyte. The linear concentration ranges for the proposed electrodes were 10 −5 -10 −2  mol L −1 for the vancomyc...

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Bibliographic Details
Published in:Instrumentation science & technology 2004-12, Vol.32 (6), p.601-610
Main Authors: Rat'ko, Alexander A., Stefan, Raluca-Ioana, van Staden, Jacobus (Koos) F., Aboul-Enein, Hassan Y.
Format: Article
Language:English
Subjects:
Acetyl-L-carnitine
Enantioselective potentiometric membrane electrode
Teicoplanin
Vancomycin
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Summary:Two enantioselective, potentiometric membrane electrodes, based on macrocyclic glycopeptide antibiotics-vancomycin and teicoplanin-were designed. Acetyl-L-carnitine was selected as model analyte. The linear concentration ranges for the proposed electrodes were 10 −5 -10 −2  mol L −1 for the vancomycin-based electrode and 10 −4 -10 −2  mol L −1 for the teicoplanin-based electrode, with slopes of 58.1 and 55.0 mV/p (acetyl-L-carnitine), respectively. The enantioselectivity was determined over D-carnitine. The surfaces of the electrodes are easily renewable by polishing on alumina paper.
ISSN:1073-9149
1525-6030
DOI:10.1081/CI-200037017