Long-term humoral immunogenicity, safety and protective efficacy of inactivated vaccine against COVID-19 (CoviVac) in preclinical studies

The unprecedented in recent history global COVID-19 pandemic urged the implementation of all existing vaccine platforms to ensure the availability of the vaccines against COVID-19 to every country in the world. Despite the multitude of high-quality papers describing clinical trials of different vacc...

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Bibliographic Details
Published in:Emerging microbes & infections 2021-01, Vol.10 (1), p.1790-1806
Main Authors: Kozlovskaya, Liubov I., Piniaeva, Anastasia N., Ignatyev, Georgy M., Gordeychuk, Ilya V., Volok, Viktor P., Rogova, Yulia V., Shishova, Anna A., Kovpak, Anastasia A., Ivin, Yury Yu, Antonova, Liliya P., Mefyod, Kirill M., Prokosheva, Lyubov S., Sibirkina, Anna S., Tarasova, Yuliya Yu, Bayurova, Ekaterina O., Gancharova, Olga S., Illarionova, Victoria V., Glukhov, Grigory S., Sokolova, Olga S., Shaitan, Konstantin V., Moysenovich, Anastasia M., Gulyaev, Stanislav A., Gulyaeva, Tatiana V., Moroz, Andrey V., Gmyl, Larissa V., Ipatova, Elena G., Kirpichnikov, Mikhail P., Egorov, Alexey M., Siniugina, Aleksandra A., Ishmukhametov, Aydar A.
Format: Article
Language:English
Subjects:
COVID-19
immunogenicity
inactivated vaccine
neutralizing antibodies
Original
preclinical study
safety
SARS-CoV-2
Vaccine
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Summary:The unprecedented in recent history global COVID-19 pandemic urged the implementation of all existing vaccine platforms to ensure the availability of the vaccines against COVID-19 to every country in the world. Despite the multitude of high-quality papers describing clinical trials of different vaccine products, basic detailed data on general toxicity, reproductive toxicity, immunogenicity, protective efficacy and durability of immune response in animal models are scarce. Here, we developed a β-propiolactone-inactivated whole virion vaccine CoviVac and assessed its safety, protective efficacy, immunogenicity and stability of the immune response in rodents and non-human primates. The vaccine showed no signs of acute/chronic, reproductive, embryo- and fetotoxicity, or teratogenic effects, as well as no allergenic properties in studied animal species. The vaccine induced stable and robust humoral immune response both in form of specific anti-SARS-CoV-2 IgG and NAbs in mice, Syrian hamsters, and common marmosets. The NAb levels did not decrease significantly over the course of one year. The course of two immunizations protected Syrian hamsters from severe pneumonia upon intranasal challenge with the live virus. Robustness of the vaccine manufacturing process was demonstrated as well. These data encouraged further evaluation of CoviVac in clinical trials.
ISSN:2222-1751
2222-1751
DOI:10.1080/22221751.2021.1971569