A systematic review and meta-analysis of the seroconversion rates and adverse effects of COVID-19 mRNA vaccine and COVID-19 viral vector vaccine in kidney transplant recipient patients

Patients received kidney transplantation (KTR) have a low seroconversion rate after vaccination. Our objective was to compare the seroconversion rates and adverse effects of additional different vaccinations in KTR patients in existing studies. Databases such as PubMed, Cochrane Library, Web of Scie...

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Bibliographic Details
Published in:Human vaccines & immunotherapeutics 2023-12, Vol.19 (1), p.2196893-2196893
Main Authors: Chen, Sikai, Wei, Wenxin, Huang, Fengyu, Wang, Jing, Li, Xingyu, Geng, Zhixin, Gao, Feng, Dong, Taiwei, Wei, Peifeng, Yang, Xinbo, Miao, Feng
Format: Article
Language:English
Subjects:
adverse effects
Antibodies, Viral
Coronavirus – Review
COVID-19
COVID-19 - prevention & control
COVID-19 Vaccines - adverse effects
Female
Humans
kidney transplant recipient
Kidney Transplantation
Male
mRNA vaccine
Review
Seroconversion
seroconversion rate
Vaccination - adverse effects
viral vector vaccine
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Summary:Patients received kidney transplantation (KTR) have a low seroconversion rate after vaccination. Our objective was to compare the seroconversion rates and adverse effects of additional different vaccinations in KTR patients in existing studies. Databases such as PubMed, Cochrane Library, Web of Science, Embase, ClinicalTrials.gov and others. Three high-quality RCT were included and showed no statistical difference in seroconversion rates between the two vaccines (RR = 0.93[0.76,1.13]). There was no statistical difference in seroconversion rates between the sexes, for men (RR = 0.93[0.69,1.25]) and women (RR = 0.91[0.62,1.33]). Among the adverse effects there was no statistically significant difference in fever (RR = 1.06[0.44,2.57]), while for injection site pain there was a statistically significant difference (RR = 1.14[1.18,1.84]). There was no significant difference in seroconversion rates in patients with KTR who received the two additional vaccines. Patients injected with the viral vector vaccine were less painful than those injected with the mRNA vaccine.
ISSN:2164-5515
2164-554X
DOI:10.1080/21645515.2023.2196893