Early versus late stage schizophrenia. What markers make the difference?

To identify the psychopathological, cognitive, functional, physical health and inflammatory markers that differentiate between early-stage schizophrenia (ESSCH) and late-stage schizophrenia (LSSCH). Cross-sectional, naturalistic study of 104 patients with SCH. The sample was divided in two groups: 3...

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Bibliographic Details
Published in:The world journal of biological psychiatry 2019-02, Vol.20 (2), p.159-165
Main Authors: García-Álvarez, L, García-Portilla, M P, Caso, J R, de la Fuente-Tomás, L, González-Blanco, L, Sáiz Martínez, P, Leza, J C, Bobes, J
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Language:English
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Summary:To identify the psychopathological, cognitive, functional, physical health and inflammatory markers that differentiate between early-stage schizophrenia (ESSCH) and late-stage schizophrenia (LSSCH). Cross-sectional, naturalistic study of 104 patients with SCH. The sample was divided in two groups: 35 ESSCH (≤7 years' duration of illness) and 69 LSSCH (>10 years' duration of illness). chi-square test and Student's t-test and ANCOVA (or Quade test) controlling for age, sex, BMI and number of cigarettes/day. Finally, a binomial logistic regression was made. ESSCH show greater negative symptom severity (t = 2.465, p = 0.015), lower levels of IκBα (F = 7.644, p = 0.007), were more frequently classified as normal weight (40% vs 18.8%, p = 0.032) compared with LSSCH. The binomial logistic regression model included age (B = 0.127, p = 0.001) and IκBα (B = 0.025, p = 0.002) and accounted for 38.9% of the variance (model df =7, chi-square =41.841, p 
ISSN:1562-2975
1814-1412
DOI:10.1080/15622975.2018.1511920