Loading…
DNA groove-binding and acid-base properties of a Ru(II) complex containing anthryl moieties
DNA groove binders have been poorly studied as compared to the intercalators. A novel Ru(II) complex of [Ru(aeip) 2 (Haip)](PF 6 ) 2 {Haip = 2-(9-anthryl)-1H-imidazo[4,5-f][1,10]phenanthroline and aeip = 2-(anthracen-9-yl)-1-ethyl-imidazo[4,5-f][1, 10]phenanthroline} is synthesized and characterized...
Saved in:
| Published in: | Nucleosides, nucleotides & nucleic acids nucleotides & nucleic acids, 2020-04, Vol.39 (4), p.592-614 |
|---|---|
| Main Authors: | , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c394t-c6b73e7af22da5a85d21f8a5aec67c16c1889914cdb077eea81e3800f2d5f9a73 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c394t-c6b73e7af22da5a85d21f8a5aec67c16c1889914cdb077eea81e3800f2d5f9a73 |
| container_end_page | 614 |
| container_issue | 4 |
| container_start_page | 592 |
| container_title | Nucleosides, nucleotides & nucleic acids |
| container_volume | 39 |
| creator | Yin, Hong-Ju Zhang, An-Guo Gao, Li-Hua Zhao, Hua Wang, Ke-Zhi |
| description | DNA groove binders have been poorly studied as compared to the intercalators. A novel Ru(II) complex of [Ru(aeip)
2
(Haip)](PF
6
)
2
{Haip = 2-(9-anthryl)-1H-imidazo[4,5-f][1,10]phenanthroline and aeip = 2-(anthracen-9-yl)-1-ethyl-imidazo[4,5-f][1, 10]phenanthroline} is synthesized and characterized by elemental analysis,
1
H NMR spectroscopy and mass spectrometry. The complex is evidenced to be a calf-thymus DNA groove binder with a large intrinsic binding constant of 10
6
M
−1
order of magnitude as supported by UV-visible absorption spectral titrations, salt effects, DNA competitive binding with ethidium bromide, DNA melting experiment, DNA viscosity measurements and density functional theory calculations. The acid-base properties of the complex studied by UV-Vis spectrophotometric titrations are reported as well. |
| doi_str_mv | 10.1080/15257770.2019.1669804 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1080_15257770_2019_1669804</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2406229185</sourcerecordid><originalsourceid>FETCH-LOGICAL-c394t-c6b73e7af22da5a85d21f8a5aec67c16c1889914cdb077eea81e3800f2d5f9a73</originalsourceid><addsrcrecordid>eNp9kEtv1DAURi0Eog_4CSBLbMoig68TP7KjaimMVIGEYMXCcvworhJ7sBNg_j2OZsqCBat7F-f77tVB6AWQDRBJ3gCjTAhBNpRAvwHOe0m6R-gUWEsb2rbs8bpT1qzQCTor5Z4QkESKp-ikBcY5AD9F364_XuK7nNJP1wwh2hDvsI4WaxNsM-ji8C6nnctzcAUnjzX-vFxst6-xSdNudL_rjLMO8ZCbv-f9iKcU3Mo_Q0-8Hot7fpzn6OvNuy9XH5rbT--3V5e3jWn7bm4MH0TrhPaUWs20ZJaCl3VzhgsD3ICUfQ-dsQMRwjktwbWSEE8t870W7Tm6OPTWV38srsxqCsW4cdTRpaUoSvu-66RkvKKv_kHv05Jj_U7RjvBKgmSVYgfK5FRKdl7tcph03isgarWvHuyr1b462q-5l8f2ZZic_Zt60F2BtwcgRJ_ypH-lPFo16_2Yss86mlAq_N8bfwAiEZLe</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2406229185</pqid></control><display><type>article</type><title>DNA groove-binding and acid-base properties of a Ru(II) complex containing anthryl moieties</title><source>Taylor and Francis Science and Technology Collection</source><creator>Yin, Hong-Ju ; Zhang, An-Guo ; Gao, Li-Hua ; Zhao, Hua ; Wang, Ke-Zhi</creator><creatorcontrib>Yin, Hong-Ju ; Zhang, An-Guo ; Gao, Li-Hua ; Zhao, Hua ; Wang, Ke-Zhi</creatorcontrib><description>DNA groove binders have been poorly studied as compared to the intercalators. A novel Ru(II) complex of [Ru(aeip)
2
(Haip)](PF
6
)
2
{Haip = 2-(9-anthryl)-1H-imidazo[4,5-f][1,10]phenanthroline and aeip = 2-(anthracen-9-yl)-1-ethyl-imidazo[4,5-f][1, 10]phenanthroline} is synthesized and characterized by elemental analysis,
1
H NMR spectroscopy and mass spectrometry. The complex is evidenced to be a calf-thymus DNA groove binder with a large intrinsic binding constant of 10
6
M
−1
order of magnitude as supported by UV-visible absorption spectral titrations, salt effects, DNA competitive binding with ethidium bromide, DNA melting experiment, DNA viscosity measurements and density functional theory calculations. The acid-base properties of the complex studied by UV-Vis spectrophotometric titrations are reported as well.</description><identifier>ISSN: 1525-7770</identifier><identifier>EISSN: 1532-2335</identifier><identifier>DOI: 10.1080/15257770.2019.1669804</identifier><identifier>PMID: 31566116</identifier><language>eng</language><publisher>United States: Taylor & Francis</publisher><subject>Animals ; anthracene ; Binding, Competitive ; Cattle ; Coordination Complexes - chemical synthesis ; Coordination Complexes - chemistry ; density functional theory ; Deoxyribonucleic acid ; DNA ; DNA - chemistry ; Ethidium - chemistry ; Ethidium bromide ; Hydrogen-Ion Concentration ; Magnetic resonance spectroscopy ; Mass spectroscopy ; Molecular Structure ; NMR ; Nuclear magnetic resonance ; Nucleic Acid Denaturation ; Ruthenium ; Ruthenium - chemistry ; Spectrophotometry ; Viscosity</subject><ispartof>Nucleosides, nucleotides & nucleic acids, 2020-04, Vol.39 (4), p.592-614</ispartof><rights>2019 Taylor & Francis Group, LLC 2019</rights><rights>2019 Taylor & Francis Group, LLC</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c394t-c6b73e7af22da5a85d21f8a5aec67c16c1889914cdb077eea81e3800f2d5f9a73</citedby><cites>FETCH-LOGICAL-c394t-c6b73e7af22da5a85d21f8a5aec67c16c1889914cdb077eea81e3800f2d5f9a73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,783,787,27936,27937</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31566116$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yin, Hong-Ju</creatorcontrib><creatorcontrib>Zhang, An-Guo</creatorcontrib><creatorcontrib>Gao, Li-Hua</creatorcontrib><creatorcontrib>Zhao, Hua</creatorcontrib><creatorcontrib>Wang, Ke-Zhi</creatorcontrib><title>DNA groove-binding and acid-base properties of a Ru(II) complex containing anthryl moieties</title><title>Nucleosides, nucleotides & nucleic acids</title><addtitle>Nucleosides Nucleotides Nucleic Acids</addtitle><description>DNA groove binders have been poorly studied as compared to the intercalators. A novel Ru(II) complex of [Ru(aeip)
2
(Haip)](PF
6
)
2
{Haip = 2-(9-anthryl)-1H-imidazo[4,5-f][1,10]phenanthroline and aeip = 2-(anthracen-9-yl)-1-ethyl-imidazo[4,5-f][1, 10]phenanthroline} is synthesized and characterized by elemental analysis,
1
H NMR spectroscopy and mass spectrometry. The complex is evidenced to be a calf-thymus DNA groove binder with a large intrinsic binding constant of 10
6
M
−1
order of magnitude as supported by UV-visible absorption spectral titrations, salt effects, DNA competitive binding with ethidium bromide, DNA melting experiment, DNA viscosity measurements and density functional theory calculations. The acid-base properties of the complex studied by UV-Vis spectrophotometric titrations are reported as well.</description><subject>Animals</subject><subject>anthracene</subject><subject>Binding, Competitive</subject><subject>Cattle</subject><subject>Coordination Complexes - chemical synthesis</subject><subject>Coordination Complexes - chemistry</subject><subject>density functional theory</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>DNA - chemistry</subject><subject>Ethidium - chemistry</subject><subject>Ethidium bromide</subject><subject>Hydrogen-Ion Concentration</subject><subject>Magnetic resonance spectroscopy</subject><subject>Mass spectroscopy</subject><subject>Molecular Structure</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Nucleic Acid Denaturation</subject><subject>Ruthenium</subject><subject>Ruthenium - chemistry</subject><subject>Spectrophotometry</subject><subject>Viscosity</subject><issn>1525-7770</issn><issn>1532-2335</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp9kEtv1DAURi0Eog_4CSBLbMoig68TP7KjaimMVIGEYMXCcvworhJ7sBNg_j2OZsqCBat7F-f77tVB6AWQDRBJ3gCjTAhBNpRAvwHOe0m6R-gUWEsb2rbs8bpT1qzQCTor5Z4QkESKp-ikBcY5AD9F364_XuK7nNJP1wwh2hDvsI4WaxNsM-ji8C6nnctzcAUnjzX-vFxst6-xSdNudL_rjLMO8ZCbv-f9iKcU3Mo_Q0-8Hot7fpzn6OvNuy9XH5rbT--3V5e3jWn7bm4MH0TrhPaUWs20ZJaCl3VzhgsD3ICUfQ-dsQMRwjktwbWSEE8t870W7Tm6OPTWV38srsxqCsW4cdTRpaUoSvu-66RkvKKv_kHv05Jj_U7RjvBKgmSVYgfK5FRKdl7tcph03isgarWvHuyr1b462q-5l8f2ZZic_Zt60F2BtwcgRJ_ypH-lPFo16_2Yss86mlAq_N8bfwAiEZLe</recordid><startdate>20200402</startdate><enddate>20200402</enddate><creator>Yin, Hong-Ju</creator><creator>Zhang, An-Guo</creator><creator>Gao, Li-Hua</creator><creator>Zhao, Hua</creator><creator>Wang, Ke-Zhi</creator><general>Taylor & Francis</general><general>Taylor & Francis Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TM</scope><scope>7X8</scope></search><sort><creationdate>20200402</creationdate><title>DNA groove-binding and acid-base properties of a Ru(II) complex containing anthryl moieties</title><author>Yin, Hong-Ju ; Zhang, An-Guo ; Gao, Li-Hua ; Zhao, Hua ; Wang, Ke-Zhi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c394t-c6b73e7af22da5a85d21f8a5aec67c16c1889914cdb077eea81e3800f2d5f9a73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Animals</topic><topic>anthracene</topic><topic>Binding, Competitive</topic><topic>Cattle</topic><topic>Coordination Complexes - chemical synthesis</topic><topic>Coordination Complexes - chemistry</topic><topic>density functional theory</topic><topic>Deoxyribonucleic acid</topic><topic>DNA</topic><topic>DNA - chemistry</topic><topic>Ethidium - chemistry</topic><topic>Ethidium bromide</topic><topic>Hydrogen-Ion Concentration</topic><topic>Magnetic resonance spectroscopy</topic><topic>Mass spectroscopy</topic><topic>Molecular Structure</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>Nucleic Acid Denaturation</topic><topic>Ruthenium</topic><topic>Ruthenium - chemistry</topic><topic>Spectrophotometry</topic><topic>Viscosity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yin, Hong-Ju</creatorcontrib><creatorcontrib>Zhang, An-Guo</creatorcontrib><creatorcontrib>Gao, Li-Hua</creatorcontrib><creatorcontrib>Zhao, Hua</creatorcontrib><creatorcontrib>Wang, Ke-Zhi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Nucleic Acids Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Nucleosides, nucleotides & nucleic acids</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yin, Hong-Ju</au><au>Zhang, An-Guo</au><au>Gao, Li-Hua</au><au>Zhao, Hua</au><au>Wang, Ke-Zhi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>DNA groove-binding and acid-base properties of a Ru(II) complex containing anthryl moieties</atitle><jtitle>Nucleosides, nucleotides & nucleic acids</jtitle><addtitle>Nucleosides Nucleotides Nucleic Acids</addtitle><date>2020-04-02</date><risdate>2020</risdate><volume>39</volume><issue>4</issue><spage>592</spage><epage>614</epage><pages>592-614</pages><issn>1525-7770</issn><eissn>1532-2335</eissn><abstract>DNA groove binders have been poorly studied as compared to the intercalators. A novel Ru(II) complex of [Ru(aeip)
2
(Haip)](PF
6
)
2
{Haip = 2-(9-anthryl)-1H-imidazo[4,5-f][1,10]phenanthroline and aeip = 2-(anthracen-9-yl)-1-ethyl-imidazo[4,5-f][1, 10]phenanthroline} is synthesized and characterized by elemental analysis,
1
H NMR spectroscopy and mass spectrometry. The complex is evidenced to be a calf-thymus DNA groove binder with a large intrinsic binding constant of 10
6
M
−1
order of magnitude as supported by UV-visible absorption spectral titrations, salt effects, DNA competitive binding with ethidium bromide, DNA melting experiment, DNA viscosity measurements and density functional theory calculations. The acid-base properties of the complex studied by UV-Vis spectrophotometric titrations are reported as well.</abstract><cop>United States</cop><pub>Taylor & Francis</pub><pmid>31566116</pmid><doi>10.1080/15257770.2019.1669804</doi><tpages>23</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1525-7770 |
| ispartof | Nucleosides, nucleotides & nucleic acids, 2020-04, Vol.39 (4), p.592-614 |
| issn | 1525-7770 1532-2335 |
| language | eng |
| recordid | cdi_crossref_primary_10_1080_15257770_2019_1669804 |
| source | Taylor and Francis Science and Technology Collection |
| subjects | Animals anthracene Binding, Competitive Cattle Coordination Complexes - chemical synthesis Coordination Complexes - chemistry density functional theory Deoxyribonucleic acid DNA DNA - chemistry Ethidium - chemistry Ethidium bromide Hydrogen-Ion Concentration Magnetic resonance spectroscopy Mass spectroscopy Molecular Structure NMR Nuclear magnetic resonance Nucleic Acid Denaturation Ruthenium Ruthenium - chemistry Spectrophotometry Viscosity |
| title | DNA groove-binding and acid-base properties of a Ru(II) complex containing anthryl moieties |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-11-13T13%3A14%3A27IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=DNA%20groove-binding%20and%20acid-base%20properties%20of%20a%20Ru(II)%20complex%20containing%20anthryl%20moieties&rft.jtitle=Nucleosides,%20nucleotides%20&%20nucleic%20acids&rft.au=Yin,%20Hong-Ju&rft.date=2020-04-02&rft.volume=39&rft.issue=4&rft.spage=592&rft.epage=614&rft.pages=592-614&rft.issn=1525-7770&rft.eissn=1532-2335&rft_id=info:doi/10.1080/15257770.2019.1669804&rft_dat=%3Cproquest_cross%3E2406229185%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c394t-c6b73e7af22da5a85d21f8a5aec67c16c1889914cdb077eea81e3800f2d5f9a73%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2406229185&rft_id=info:pmid/31566116&rfr_iscdi=true |