Glycoside constituents of Camellia amplexicaulis and their α-glucosidase inhibitory activity

Four new glycosides, named amplexicosides A-D (1-4), and five known compounds: benzyl 2-[β-D-glucopyranosyl-(1→6)-β-D-glucopyranosyloxy]-benzoate (5), benzyl 2-neohesperidosyloxy-6-hydroxybenzoate (6), chrysandroside A (7), chrysandroside B (8) and camelliquercetiside C (9) were isolated from the br...

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Published in:Natural product research 2024-03, Vol.38 (5), p.759-767
Main Authors: Cuc, Nguyen Thi, Dung, Duong Thi, Bang, Ngo Anh, Yen, Duong Thi Hai, Huy Hoang, Nguyen, Kiem, Phan Van, Tai, Bui Huu
Format: Article
Language:English
Subjects:
alpha-Glucosidases
amplexicoside
benzoate derivative
Benzoates
Benzoic acid
Camellia
Camellia amplexicaulis
Cardiac Glycosides
flavonol glycoside
Glucosidase
Glycoside Hydrolase Inhibitors - chemistry
Glycoside Hydrolase Inhibitors - pharmacology
Glycosides
Glycosides - chemistry
Glycosides - pharmacology
Molecular Structure
NMR
Nuclear magnetic resonance
α-Glucosidase
α-glucosidase inhibitor
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Summary:Four new glycosides, named amplexicosides A-D (1-4), and five known compounds: benzyl 2-[β-D-glucopyranosyl-(1→6)-β-D-glucopyranosyloxy]-benzoate (5), benzyl 2-neohesperidosyloxy-6-hydroxybenzoate (6), chrysandroside A (7), chrysandroside B (8) and camelliquercetiside C (9) were isolated from the branches and leaves of Camellia amplexicaulis (Pit.) Cohen-Stuart. Their structures were elucidated using HR-ESI-MS and 1D- and 2D-NMR spectra and compared to reported NMR data. All of the isolated compounds were screened in an α-glucosidase assay. Compounds 4, 8, and 9 significantly inhibited α-glucosidase with respective IC 50 values of 254.9 ± 4.2, 304.8 ± 11.9 and 228.1 ± 16.4 μM.
ISSN:1478-6419
1478-6427
DOI:10.1080/14786419.2023.2196724