Identification Of Potential Cytotoxic Inhibitors From Physalis Minima

A phytochemical investigation of Physalis minima led to the isolation of six withanolides, including withanolide E (1), withaperuvin C (2), 4β-hydroxywithanolide E (3), 28-hydroxywithaperuvin C (4), physaperuvin G (5), and 4-deoxywithaperuvin (6). Their chemical structures were elucidated by 1 D-NMR...

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Bibliographic Details
Published in:Natural product research 2021-06, Vol.35 (12), p.2082-2085
Main Authors: Le Canh, Viet Cuong, Le Ba, Vinh, Thi Hai Yen, Pham, Le Thi, Lien, Thi Thuy Hoai, Pham, Huu Dat, Ton That, Thao, Do Thi, Bach, Long Giang, Kim, Young Ho, Tuan Anh, Hoang Le
Format: Article
Language:English
Subjects:
anti-cancer
cytotoxic activity
Cytotoxicity
NMR
Nuclear magnetic resonance
Physalis minima
Toxicity
Tumor cell lines
withanolide
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Summary:A phytochemical investigation of Physalis minima led to the isolation of six withanolides, including withanolide E (1), withaperuvin C (2), 4β-hydroxywithanolide E (3), 28-hydroxywithaperuvin C (4), physaperuvin G (5), and 4-deoxywithaperuvin (6). Their chemical structures were elucidated by 1 D-NMR and 2 D-NMR data, as well as comparison with the data reported in the literature. All isolated compounds were evaluated for their cytotoxic activity against HepG2, SK-LU-1, and MCF7 cancer cell lines. As the obtained results, compounds 1 and 3 displayed the strongest cytotoxicity against HepG2, SK-LU-1, and MCF7 cell lines with IC 50 value ranging from 0.051 ± 0.004 to 0.86 ± 0.09 μg/mL.
ISSN:1478-6419
1478-6427
DOI:10.1080/14786419.2019.1650360