Lipoxygenase inhibiting ethyl substituted glycoside from Symplocos racemosa

Phytochemical investigation of Symplocos racemosa resulted in the isolation of a new ethyl substituted glycoside, 1-ethyl brachiose-3′-acetate (1) along with four known compounds ketochaulmoogric acid (2), nonaeicosanol (3), triacontyl palmitate (4) and methyl triacontanoate (5). The substitution of...

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Bibliographic Details
Published in:Natural product research 2005-07, Vol.19 (5), p.509-515
Main Authors: Abbasi †, Muhammad Athar, Ahmad, Viqar Uddin, Zubair, Muhammad, Nawaz, Sarfraz A., Lodhi, Muhammad Arif, Farooq, Umar, Choudhary, M. Iqbal
Format: Article
Language:English
Subjects:
Glycoside
Glycosides - chemistry
Glycosides - pharmacology
Lipoxygenase
Lipoxygenase Inhibitors - chemistry
Lipoxygenase Inhibitors - pharmacology
Magnoliopsida - chemistry
Molecular Structure
Symplocos racemosa Roxb. (Lodh)
Urease
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Summary:Phytochemical investigation of Symplocos racemosa resulted in the isolation of a new ethyl substituted glycoside, 1-ethyl brachiose-3′-acetate (1) along with four known compounds ketochaulmoogric acid (2), nonaeicosanol (3), triacontyl palmitate (4) and methyl triacontanoate (5). The substitution of ethyl group on 1 was natural because during the course of extraction and purification ethanol was not used. The structural elucidation of the isolated compounds was based primarily on 1D- and 2D-NMR analysis, including COSY, HMQC, and HMBC correlations. The glycoside 1 and triacontyl palmitate (4) displayed the inhibitory potential against lipoxygenase and urease enzyme, respectively.
ISSN:1478-6419
1478-6427
DOI:10.1080/1478641042000261978