Relationships between 25(OH)D concentration, sarcopenia and HOMA-IR in postmenopausal Korean women

Objective: Sarcopenia and insulin resistance are common co-morbidities in the elderly and are known to be associated with vitamin D deficiency. However, no previous studies have investigated interactions between all three of these factors. We aimed to investigate the relationship between 25-hydroxyv...

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Bibliographic Details
Published in:Climacteric : the journal of the International Menopause Society 2018-02, Vol.21 (1), p.40-46
Main Authors: Lee, J. H., Kim, S., Kim, M. K., Yun, B. H., Cho, S., Choi, Y. S., Lee, B. S., Seo, S. K.
Format: Article
Language:English
Subjects:
Glucose
HOMA-IR
Insulin resistance
postmenopausal
Sarcopenia
Vitamin D
Vitamin deficiency
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Summary:Objective: Sarcopenia and insulin resistance are common co-morbidities in the elderly and are known to be associated with vitamin D deficiency. However, no previous studies have investigated interactions between all three of these factors. We aimed to investigate the relationship between 25-hydroxyvitamin D concentration, sarcopenia, and insulin resistance in postmenopausal Korean women. Methods: This study used data from the Korea National Health and Nutrition Examination Survey 2008-2011. Participants were 3744 postmenopausal Korean women. Sarcopenia was defined as appendicular skeletal muscle mass divided by body weight >1 standard deviation below the mean for women aged 20-40 years. The serum 25-hydroxyvitamin D and fasting insulin levels were measured, and insulin resistance was calculated using the formula: fasting plasma glucose (mg/dl) × fasting insulin (mIU/l)/405. Results: We found a strong inverse association between 25-hydroxyvitamin D concentration and sarcopenia in postmenopausal Korean women (p = 0.0009). There was also a significant association between sarcopenia and insulin resistance, independent of vitamin D and obesity status (p 
ISSN:1369-7137
1473-0804
DOI:10.1080/13697137.2017.1395410