The platelet-to-lymphocyte ratio as a predictor of patient outcomes in ovarian cancer: a meta-analysis

Objectives: The platelet-to-lymphocyte ratio (PLR) is a predictive clinical biomarker for different cancers. However, the results of several studies investigating the association between the PLR and the prognosis of ovarian cancer have been inconclusive. Therefore, there is a need to conduct a meta-...

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Bibliographic Details
Published in:Climacteric : the journal of the International Menopause Society 2017-10, Vol.20 (5), p.448-455
Main Authors: Ma, X-M., Sun, X., Yang, G-W., Yu, M-W., Zhang, G-L., Yu, J., Zhang, Y., Wang, X-M.
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Blood platelets
Diagnosis, Differential
Female
Humans
Lymphocyte Count
Lymphocytes
Medical prognosis
MEDLINE
Meta-analysis
Middle Aged
Ovarian cancer
Ovarian Neoplasms - blood
Ovarian Neoplasms - diagnosis
Ovarian Neoplasms - mortality
Platelet Count
Platelet-to-lymphocyte ratio
Prognosis
Proportional Hazards Models
Risk Factors
Survival Rate
Womens health
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Summary:Objectives: The platelet-to-lymphocyte ratio (PLR) is a predictive clinical biomarker for different cancers. However, the results of several studies investigating the association between the PLR and the prognosis of ovarian cancer have been inconclusive. Therefore, there is a need to conduct a meta-analysis to estimate the prognostic value of the PLR in ovarian cancer. Methods: We searched the EMBASE, Medline, PubMed, and Web of Science databases to identify clinical studies that had evaluated the association between the PLR and ovarian cancer prognosis. Outcomes evaluated included overall survival (OS) and progression-free survival (PFS). We also analyzed PLR differences between malignant ovarian masses and the controls. Results: Twelve relevant studies that comprised 2340 patients were selected for the meta-analysis. The results revealed that elevated PLR was significantly associated with poor OS (hazard ratio (HR) 1.63, 95% confidence interval (CI) 1.05-2.56, p 
ISSN:1369-7137
1473-0804
DOI:10.1080/13697137.2017.1326894