Biomarkers in patients with Takotsubo cardiomyopathy compared to patients with acute anterior ST-elevation myocardial infarction

Background: Takotsubo cardiomyopathy (TTC) is a syndrome of acute non-coronary heart failure with similar symptoms and electrocardiograms to acute anterior ST-elevation myocardial infarction (STEMI). Little is known about the pathophysiology of TTC. We assessed admission plasma concentrations of bio...

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Bibliographic Details
Published in:Biomarkers 2020-02, Vol.25 (2), p.137-143
Main Authors: Højagergaard, Mathias Alexander, Hassager, Christian, Christensen, Thomas Emil, Bang, Lia Evi, Gøtze, Jens Peter, Ostrowski, Sisse Rye, Holmvang, Lene, Frydland, Martin
Format: Article
Language:English
Subjects:
copeptin
inflammation
mid-regional pro-adrenomedullin
neuroendocrine response
pro-atrial natriuretic peptide
soluble thrombomodulin
ST-elevation myocardial infarction
suppression of tumorigenicity 2
syndecan-1
Takotsubo cardiomyopathy
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Summary:Background: Takotsubo cardiomyopathy (TTC) is a syndrome of acute non-coronary heart failure with similar symptoms and electrocardiograms to acute anterior ST-elevation myocardial infarction (STEMI). Little is known about the pathophysiology of TTC. We assessed admission plasma concentrations of biomarkers reflecting neuroendocrine response (copeptin, mid-regional-pro-adrenomedullin, pro-atrial-natriuretic-peptide, soluble thrombomodulin (sTM), syndecan-1) and inflammation (suppression-of-tumorigenicity 2 (ST2), high-sensitive C-reactive-protein) in TTC patients and compared to patients with acute anterior STEMI. Materials and methods: Twenty TTC patients were matched with 40 STEMI patients by age, gender and left ventricular ejection fraction. Blood was sampled upon hospital admission immediately before acute coronary angiography. Results: The groups had similar comorbidities. TTC patients had higher plasma concentrations of sTM: 7.94 (5.89;9.61) vs. 6.42 (5.50;7.82)ng/ml, p = 0.04 and ST2 (53 (32;157) vs. 45 (31;55)ng/ml, p = 0.008) and higher heart rate: 101 ( 33) vs. 76( 14)bpm, p = 0.0001, but lower concentrations of copeptin (10.4 (7.6;39) vs. 92.3 (13;197)pmol/l, p 
ISSN:1354-750X
1366-5804
DOI:10.1080/1354750X.2019.1710767